| Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production | |
| Yu, Xinfang1,2,3,4; Li, Wei1,2,5; Deng, Qipan1,2; You, Shuo6; Liu, Haidan6; Peng, Songling1,2; Liu, Xiaolan1,2; Lu, Jingchen1,2; Luo, Xiangjian1,2; Yang, Lifang1,2; Tang, Min1,2; Weng, Xinxian1,2; Yi, Wei1,2; Liu, Wenbin3,4; Wu, Shengqi3,4; Ding, Zhihui7; Feng, Tao7; Zhou, Jian8; Fan, Jia8; Bode, Ann M.9; Dong, Zigang9; Liu, Jikai7; Cao, Ya1,2 | |
| 2017-05-01 | |
| 发表期刊 | MOLECULAR CARCINOGENESIS
 |
| 卷号 | 56期号:5页码:1414-1426 |
| 摘要 | Neoalbaconol, derived from Albatrellus confluens, shows anti-cancer activities in the previously study, but its role in angiogenesis is unknown. Here, we determined whether neoalbaconol could attenuate angiogenesis and how does it occur. Data demonstrated that neoalbaconol could inhibit the proliferation of breast cancer cells and induce apoptosis. Also, neoalbaconol suppressed vascular endothelial growth factor (VEGF)-induced human umbilical vascular endothelial cells (HUVECs) proliferation, migration, invasion, and capillary-like tube formation in vitro and reduced tumor angiogenesis in vivo. VEGF receptor activation and the downstream signal transduction cascades activation were inhibited by neoalbaconol. Additionally, neoalbaconol blocked EGFR-mediated VEGF production. EGFR overexpression reversed the neoalbaconol-induced VEGF reduction, confirming the importance of the EGFR inhibition in anti-angiogenesis of neoalbaconol. Furthermore, neoalbaconol inhibited tumor growth and tumor angiogenesis in a breast cancer xenograft model in vivo. Taken together, these results indicate that neoalbaconol could inhibit tumor angiogenesis and growth through direct suppression effects on vascular endothelial cells and reduction of proangiogenic factors in cancer cells. |
| 关键词 | Angiogenesis Breast Cancer Egfr Neoalbaconol Vegf |
| DOI | 10.1002/mc.22602 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000399592100004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/51192 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Cent S Univ, Key Lab Canc Carcinogenesis & Invas, Chinese Minist Educ, Xiangya Hosp, Changsha, Hunan, Peoples R China 2.Cent S Univ, Xiangya Sch Med, Canc Res Inst, 110 Xiang Ya Rd, Changsha, Hunan, Peoples R China 3.Cent S Univ, Xiangya Sch Med, Hunan Canc Hosp, Changsha, Hunan, Peoples R China 4.Cent S Univ, Xiangya Sch Med, Affiliated Canc Hosp, Changsha, Hunan, Peoples R China 5.Cent S Univ, Xiangya Hosp 3, Dept Radiol, Changsha, Hunan, Peoples R China 6.Cent S Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China 7.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 8.Zhongshan Hosp, Liver Canc Inst, Chinese Minist Publ Hlth, Key Lab Carcinogenesis, Shanghai, Peoples R China 9.Univ Minnesota, Hormel Inst, 801 16th Ave NE, Austin, MN 55912 USA |
| 推荐引用方式 GB/T 7714 | Yu, Xinfang,Li, Wei,Deng, Qipan,et al. Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production[J]. MOLECULAR CARCINOGENESIS,2017,56(5):1414-1426. |
| APA | Yu, Xinfang.,Li, Wei.,Deng, Qipan.,You, Shuo.,Liu, Haidan.,...&Cao, Ya.(2017).Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production.MOLECULAR CARCINOGENESIS,56(5),1414-1426. |
| MLA | Yu, Xinfang,et al."Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production".MOLECULAR CARCINOGENESIS 56.5(2017):1414-1426. |
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