Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum
Gao, Fei1; Yao, Yuan-Cheng1; Cai, Sheng-Bao1; Zhao, Tian-Rui1; Yang, Xiao-Yan2; Fan, Jian1; Li, Xiao-Nian3; Cao, Jian-Xin1; Cheng, Gui-Guang1
2017-04-01
Source PublicationFITOTERAPIA
Volume118Pages:107-111
AbstractPhytochemical investigation on the leaves of Epigynum auritum led to the isolation of three novel C-21 pregnane glycosides, epigynosides, E-G (1-3), together with two known pregnane glycosides, epigynosides A (4) and C (5). Their structures were elucidated based on extensive spectroscopic data (MS, IR, ID and 2D NMR) analysis, as well as comparison with the reported data. The immunological activities of the new compounds was evaluated against concanavalin A (Con A)-stimulated proliferation of mice splenocyte in vitro. Compounds 1-3 displayed significant immunosuppressive activities, close to the efficacy of the positive control (dexamethasone) at the concentration of 50 mu M. (C) 2017 Elsevier B.V. All rights reserved.
KeywordEpigynum Auritum Epigynosides E-g Pregnane Glycosides Immunosuppressive
DOI10.1016/j.fitote.2017.02.011
Indexed BySCI
Language英语
WOS IDWOS:000399261700018
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/51188
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Kunming Univ Sci & Technol, Yunnan Inst Food Safety, Kunming 6505000, Peoples R China
2.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 6505000, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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GB/T 7714
Gao, Fei,Yao, Yuan-Cheng,Cai, Sheng-Bao,et al. Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum[J]. FITOTERAPIA,2017,118:107-111.
APA Gao, Fei.,Yao, Yuan-Cheng.,Cai, Sheng-Bao.,Zhao, Tian-Rui.,Yang, Xiao-Yan.,...&Cheng, Gui-Guang.(2017).Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum.FITOTERAPIA,118,107-111.
MLA Gao, Fei,et al."Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum".FITOTERAPIA 118(2017):107-111.
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