| Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum | |
| Gao, Fei1; Yao, Yuan-Cheng1; Cai, Sheng-Bao1; Zhao, Tian-Rui1; Yang, Xiao-Yan2; Fan, Jian1; Li, Xiao-Nian3; Cao, Jian-Xin1; Cheng, Gui-Guang1 | |
| 2017-04-01 | |
| Source Publication | FITOTERAPIA
 |
| Volume | 118Pages:107-111 |
| Abstract | Phytochemical investigation on the leaves of Epigynum auritum led to the isolation of three novel C-21 pregnane glycosides, epigynosides, E-G (1-3), together with two known pregnane glycosides, epigynosides A (4) and C (5). Their structures were elucidated based on extensive spectroscopic data (MS, IR, ID and 2D NMR) analysis, as well as comparison with the reported data. The immunological activities of the new compounds was evaluated against concanavalin A (Con A)-stimulated proliferation of mice splenocyte in vitro. Compounds 1-3 displayed significant immunosuppressive activities, close to the efficacy of the positive control (dexamethasone) at the concentration of 50 mu M. (C) 2017 Elsevier B.V. All rights reserved. |
| Keyword | Epigynum Auritum Epigynosides E-g Pregnane Glycosides Immunosuppressive |
| DOI | 10.1016/j.fitote.2017.02.011 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000399261700018 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/51188 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Kunming Univ Sci & Technol, Yunnan Inst Food Safety, Kunming 6505000, Peoples R China 2.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 6505000, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China |
| Recommended Citation GB/T 7714 | Gao, Fei,Yao, Yuan-Cheng,Cai, Sheng-Bao,et al. Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum[J]. FITOTERAPIA,2017,118:107-111. |
| APA | Gao, Fei.,Yao, Yuan-Cheng.,Cai, Sheng-Bao.,Zhao, Tian-Rui.,Yang, Xiao-Yan.,...&Cheng, Gui-Guang.(2017).Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum.FITOTERAPIA,118,107-111. |
| MLA | Gao, Fei,et al."Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum".FITOTERAPIA 118(2017):107-111. |
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| 1-s2.0-S0367326X1630（623KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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