Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers

doi:10.1111/jphp.12687

	Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers
	Li, Fei 1,2; Howard, Karyn D.1; Myers, Michael J.1
	2017-03-01
发表期刊	JOURNAL OF PHARMACY AND PHARMACOLOGY
卷号	69 期号:3 页码:274-284
摘要	Objectives P-glycoprotein (P-gp) is responsible for the efflux of a broad variety of human and veterinary drugs. Canine P-gp polymorphisms alter drug disposition and toxicity, but their impact on the disposition of enantiomeric drugs is unknown. Using fexofenadine as a model compound, we developed and validated HPLC-fluorescence methods to determine the effect of P-gp on the disposition of fexofenadine and its enantiomers.
关键词	Abcb1-1 Delta Collies Enantiomer Fexofenadine Fluorescence
DOI	10.1111/jphp.12687
收录类别	SCI
语种	英语
WOS记录号	WOS:000395189200006
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/51001
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.US FDA, Div Appl Vet Res, Res Off, Ctr Vet Med, Laurel, MD USA 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Li, Fei,Howard, Karyn D.,Myers, Michael J.. Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY,2017,69(3):274-284.
APA	Li, Fei,Howard, Karyn D.,&Myers, Michael J..(2017).Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers.JOURNAL OF PHARMACY AND PHARMACOLOGY,69(3),274-284.
MLA	Li, Fei,et al."Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers".JOURNAL OF PHARMACY AND PHARMACOLOGY 69.3(2017):274-284.

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