中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 资源植物与生物技术所级重点实验室  > 期刊论文
题名: Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi
作者: Yang, Yan-long1; Zhang, Shasha3; Ma, Ke1, 2; Xu, Yuxing4; Tao, Qiaoqiao1, 2; Chen, Yihua5; Chen, Juan6, 7; Guo, Shunxing6, 7; Ren, Jinwei1; Wang, Wenzhao1; Tao, Yong3; Yin, Wen-Bing1, 2; Liu, Hongwei1, 2
刊名: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
关键词: biosynthesis ; cyclases ; diterpenes ; natural products ; UbiA
英文摘要: Diterpene cyclases from bacteria and basidiomycete fungi are seldom studied. Here, we presented the identification and verification of EriG, a member of the UbiA superfamily, as the enzyme responsible for the cyclization of the cyathane skeleton in the mushroom Hericium erinaceum. Genome mining using the EriG protein sequence as a probe led to the discovery of a new family of ubiquitous UbiA-related diterpene cyclases in bacteria and fungi. We successfully characterized seven new diterpene cyclases from bacteria or basidiomycete fungi with the help of an engineered Escherichia coli strain and determined the structures of their corresponding products. A new diterpene with an unusual skeleton was generated during this process. The discovery of this new family of diterpene cyclases provides new insight into the UbiA superfamily.
出版日期: 2017-04-18
卷号: 56, 期号:17, 页码:4749-4752
DOI标识: 10.1002/anie.201700565
语种: 英语
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/50995
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
anie201700565.pdf(2077KB)期刊论文作者接受稿开放获取View Download

作者单位: 1.Chinese Acad Sci, State Key Lab Mycol, Inst Microbiol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Microbiol, Key Lab Microbial Physiol & Metab Engn, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China
5.Chinese Acad Sci, State Key Lab Microbial Resources, Yunnan Inst Microbiol, Beijing 100101, Peoples R China
6.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
7.Peking Union Med Coll, Beijing 100193, Peoples R China

Recommended Citation:
Yang, Yan-long,Zhang, Shasha,Ma, Ke,et al. Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2017,56(17):4749-4752.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Yan-long]'s Articles
[Zhang, Shasha]'s Articles
[Ma, Ke]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Yan-long]‘s Articles
[Zhang, Shasha]‘s Articles
[Ma, Ke]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: anie201700565.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace