Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi
Yang, Yan-long1; Zhang, Shasha3; Ma, Ke1,2; Xu, Yuxing4; Tao, Qiaoqiao1,2; Chen, Yihua5; Chen, Juan6,7; Guo, Shunxing6,7; Ren, Jinwei1; Wang, Wenzhao1; Tao, Yong3; Yin, Wen-Bing1,2; Liu, Hongwei1,2
2017-04-18
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷号56期号:17页码:4749-4752
摘要Diterpene cyclases from bacteria and basidiomycete fungi are seldom studied. Here, we presented the identification and verification of EriG, a member of the UbiA superfamily, as the enzyme responsible for the cyclization of the cyathane skeleton in the mushroom Hericium erinaceum. Genome mining using the EriG protein sequence as a probe led to the discovery of a new family of ubiquitous UbiA-related diterpene cyclases in bacteria and fungi. We successfully characterized seven new diterpene cyclases from bacteria or basidiomycete fungi with the help of an engineered Escherichia coli strain and determined the structures of their corresponding products. A new diterpene with an unusual skeleton was generated during this process. The discovery of this new family of diterpene cyclases provides new insight into the UbiA superfamily.
关键词Biosynthesis Cyclases Diterpenes Natural Products Ubia
资助信息Ministry of Science and Technology of China(2014CB138304); National Natural Science Foundation of China(81673334; 21472233)
DOI10.1002/anie.201700565
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000398576000010
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/50995
专题资源植物与生物技术所级重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Mycol, Inst Microbiol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Microbiol, Key Lab Microbial Physiol & Metab Engn, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China
5.Chinese Acad Sci, State Key Lab Microbial Resources, Yunnan Inst Microbiol, Beijing 100101, Peoples R China
6.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
7.Peking Union Med Coll, Beijing 100193, Peoples R China
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Yang, Yan-long,Zhang, Shasha,Ma, Ke,et al. Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2017,56(17):4749-4752.
APA Yang, Yan-long.,Zhang, Shasha.,Ma, Ke.,Xu, Yuxing.,Tao, Qiaoqiao.,...&Liu, Hongwei.(2017).Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,56(17),4749-4752.
MLA Yang, Yan-long,et al."Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56.17(2017):4749-4752.
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