Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha

doi:10.1039/b501932j

	Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha
	Li, RT ; Han, QB ; Zheng, YT ; Wang, RR ; Yang, LM ; Lu, Y ; Sang, SQ ; Zheng, QT ; Zhao, QS; Sun, HD
	2005
发表期刊	CHEMICAL COMMUNICATIONS
期号	23 页码:2936-2938
摘要	Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C ( 2) exhibited an EC50 value of 7.71 mu g/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.
学科领域	Chemistry, Multidisciplinary
DOI	10.1039/b501932j
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000229785100013
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/5078
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China 4.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Li, RT,Han, QB,Zheng, YT,et al. Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha[J]. CHEMICAL COMMUNICATIONS,2005(23):2936-2938.
APA	Li, RT.,Han, QB.,Zheng, YT.,Wang, RR.,Yang, LM.,...&Sun, HD.(2005).Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha.CHEMICAL COMMUNICATIONS(23),2936-2938.
MLA	Li, RT,et al."Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha".CHEMICAL COMMUNICATIONS .23(2005):2936-2938.

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