Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha
Li, RT; Han, QB; Zheng, YT; Wang, RR; Yang, LM; Lu, Y; Sang, SQ; Zheng, QT; Zhao, QS; Sun, HD
2005
Source PublicationCHEMICAL COMMUNICATIONS
Issue23Pages:2936-2938
AbstractTwo new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C ( 2) exhibited an EC50 value of 7.71 mu g/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.
Subject AreaChemistry, Multidisciplinary
DOI10.1039/b501932j
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000229785100013
Citation statistics
Cited Times:82[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/5078
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
4.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
Recommended Citation
GB/T 7714
Li, RT,Han, QB,Zheng, YT,et al. Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha[J]. CHEMICAL COMMUNICATIONS,2005(23):2936-2938.
APA Li, RT.,Han, QB.,Zheng, YT.,Wang, RR.,Yang, LM.,...&Sun, HD.(2005).Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha.CHEMICAL COMMUNICATIONS(23),2936-2938.
MLA Li, RT,et al."Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha".CHEMICAL COMMUNICATIONS .23(2005):2936-2938.
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