| Bioactive flavones and biflavones from Selaginella moellendorffii Hieron | |
Cao, Yuan1; Tan, Nin-Hua3; Chen, Ji-Jun3 ; Zeng, Guang-Zhi3; Ma, Yun-Bao3; Wu, Yong-Ping2; Yan, He3; Yang, Jie1; Lu, Lai-Feng1; Wang, Qiang1
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| 2010-06-01 | |
| 发表期刊 | FITOTERAPIA
 |
| ISSN | 0367-326X |
| 卷号 | 81期号:4页码:253-258 |
| 摘要 | Three new flavones named 5-carboxymethyl-4',7-dihydroxyflavone (1), its ethyl ester (2) and butyl ester (3) were isolated from the herb Selaginella moellendorffii Hieron., together with ten known compounds. Their structures were elucidated on the basis of spectroscopic and chemical analysis. Selected compounds were evaluated for their anti-HBV and cytotoxic activity. Among them, compounds 2 and 3 displayed inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC(50) values of 0.17 mg/ml and 0.46 mg/ml, and on HBV e antigen (HBeAg) secretion with IC(50) values of 0.42 mg/ml and 0.42 mg/ml, respectively. Compounds 7.8. 10 and 12 exhibited selective cytotoxicity against the three human cancer cell lines tested. (C) 2009 Elsevier By. All rights reserved. |
| 关键词 | Selaginella Moellendorffii Selaginellacea Flavone Biflavone Anti-hbv Activity Cytotoxicity |
| 学科领域 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1016/j.fitote.2009.09.007 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000277699400006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/4974 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.China Pharmaceut Univ, Dept Chinese Mat Med Anal, Nanjing 210009, Peoples R China 2.Jiangsu Prov Inst Mat Med, Nanjing 210009, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Yuan,Tan, Nin-Hua,Chen, Ji-Jun,et al. Bioactive flavones and biflavones from Selaginella moellendorffii Hieron[J]. FITOTERAPIA,2010,81(4):253-258. |
| APA | Cao, Yuan.,Tan, Nin-Hua.,Chen, Ji-Jun.,Zeng, Guang-Zhi.,Ma, Yun-Bao.,...&Wang, Qiang.(2010).Bioactive flavones and biflavones from Selaginella moellendorffii Hieron.FITOTERAPIA,81(4),253-258. |
| MLA | Cao, Yuan,et al."Bioactive flavones and biflavones from Selaginella moellendorffii Hieron".FITOTERAPIA 81.4(2010):253-258. |
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