Bioactive flavones and biflavones from Selaginella moellendorffii Hieron
Cao, Yuan1; Tan, Nin-Hua3; Chen, Ji-Jun3; Zeng, Guang-Zhi3; Ma, Yun-Bao3; Wu, Yong-Ping2; Yan, He3; Yang, Jie1; Lu, Lai-Feng1; Wang, Qiang1
2010-06-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号81期号:4页码:253-258
摘要Three new flavones named 5-carboxymethyl-4',7-dihydroxyflavone (1), its ethyl ester (2) and butyl ester (3) were isolated from the herb Selaginella moellendorffii Hieron., together with ten known compounds. Their structures were elucidated on the basis of spectroscopic and chemical analysis. Selected compounds were evaluated for their anti-HBV and cytotoxic activity. Among them, compounds 2 and 3 displayed inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC(50) values of 0.17 mg/ml and 0.46 mg/ml, and on HBV e antigen (HBeAg) secretion with IC(50) values of 0.42 mg/ml and 0.42 mg/ml, respectively. Compounds 7.8. 10 and 12 exhibited selective cytotoxicity against the three human cancer cell lines tested. (C) 2009 Elsevier By. All rights reserved.
关键词Selaginella Moellendorffii Selaginellacea Flavone Biflavone Anti-hbv Activity Cytotoxicity
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1016/j.fitote.2009.09.007
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000277699400006
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4974
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.China Pharmaceut Univ, Dept Chinese Mat Med Anal, Nanjing 210009, Peoples R China
2.Jiangsu Prov Inst Mat Med, Nanjing 210009, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
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Cao, Yuan,Tan, Nin-Hua,Chen, Ji-Jun,et al. Bioactive flavones and biflavones from Selaginella moellendorffii Hieron[J]. FITOTERAPIA,2010,81(4):253-258.
APA Cao, Yuan.,Tan, Nin-Hua.,Chen, Ji-Jun.,Zeng, Guang-Zhi.,Ma, Yun-Bao.,...&Wang, Qiang.(2010).Bioactive flavones and biflavones from Selaginella moellendorffii Hieron.FITOTERAPIA,81(4),253-258.
MLA Cao, Yuan,et al."Bioactive flavones and biflavones from Selaginella moellendorffii Hieron".FITOTERAPIA 81.4(2010):253-258.
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