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题名: Bioactive flavones and biflavones from Selaginella moellendorffii Hieron
作者: Cao, Yuan1; Tan, Nin-Hua3; null(陈纪军)3; Zeng, Guang-Zhi3; Ma, Yun-Bao3; Wu, Yong-Ping2; Yan, He3; Yang, Jie1; Lu, Lai-Feng1; Wang, Qiang1
刊名: FITOTERAPIA
关键词: Selaginella moellendorffii ; Selaginellacea ; Flavone ; Biflavone ; Anti-HBV activity ; Cytotoxicity
英文摘要: Three new flavones named 5-carboxymethyl-4',7-dihydroxyflavone (1), its ethyl ester (2) and butyl ester (3) were isolated from the herb Selaginella moellendorffii Hieron., together with ten known compounds. Their structures were elucidated on the basis of spectroscopic and chemical analysis. Selected compounds were evaluated for their anti-HBV and cytotoxic activity. Among them, compounds 2 and 3 displayed inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC(50) values of 0.17 mg/ml and 0.46 mg/ml, and on HBV e antigen (HBeAg) secretion with IC(50) values of 0.42 mg/ml and 0.42 mg/ml, respectively. Compounds 7.8. 10 and 12 exhibited selective cytotoxicity against the three human cancer cell lines tested. (C) 2009 Elsevier By. All rights reserved.
出版日期: 2010-06-01
卷号: 81, 期号:4, 页码:253-258
DOI标识: 10.1016/j.fitote.2009.09.007
语种: 英语
ISSN号: 0367-326X
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4974
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.China Pharmaceut Univ, Dept Chinese Mat Med Anal, Nanjing 210009, Peoples R China
2.Jiangsu Prov Inst Mat Med, Nanjing 210009, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

Recommended Citation:
Cao, Y; Tan, NH; Chen, JJ; Zeng, GZ; Ma, YB; Wu, YP; Yan, H; Yang, J; Lu, LF; Wang, Q.Bioactive flavones and biflavones from Selaginella moellendorffii Hieron,FITOTERAPIA,2010,81(4):253-258
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