Bioactive flavones and biflavones from Selaginella moellendorffii Hieron
Cao, Yuan1; Tan, Nin-Hua3; Chen, Ji-Jun3; Zeng, Guang-Zhi3; Ma, Yun-Bao3; Wu, Yong-Ping2; Yan, He3; Yang, Jie1; Lu, Lai-Feng1; Wang, Qiang1
2010-06-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume81Issue:4Pages:253-258
AbstractThree new flavones named 5-carboxymethyl-4',7-dihydroxyflavone (1), its ethyl ester (2) and butyl ester (3) were isolated from the herb Selaginella moellendorffii Hieron., together with ten known compounds. Their structures were elucidated on the basis of spectroscopic and chemical analysis. Selected compounds were evaluated for their anti-HBV and cytotoxic activity. Among them, compounds 2 and 3 displayed inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC(50) values of 0.17 mg/ml and 0.46 mg/ml, and on HBV e antigen (HBeAg) secretion with IC(50) values of 0.42 mg/ml and 0.42 mg/ml, respectively. Compounds 7.8. 10 and 12 exhibited selective cytotoxicity against the three human cancer cell lines tested. (C) 2009 Elsevier By. All rights reserved.
KeywordSelaginella Moellendorffii Selaginellacea Flavone Biflavone Anti-hbv Activity Cytotoxicity
Subject AreaChemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1016/j.fitote.2009.09.007
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000277699400006
Citation statistics
Cited Times:36[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4974
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.China Pharmaceut Univ, Dept Chinese Mat Med Anal, Nanjing 210009, Peoples R China
2.Jiangsu Prov Inst Mat Med, Nanjing 210009, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Cao, Yuan,Tan, Nin-Hua,Chen, Ji-Jun,et al. Bioactive flavones and biflavones from Selaginella moellendorffii Hieron[J]. FITOTERAPIA,2010,81(4):253-258.
APA Cao, Yuan.,Tan, Nin-Hua.,Chen, Ji-Jun.,Zeng, Guang-Zhi.,Ma, Yun-Bao.,...&Wang, Qiang.(2010).Bioactive flavones and biflavones from Selaginella moellendorffii Hieron.FITOTERAPIA,81(4),253-258.
MLA Cao, Yuan,et al."Bioactive flavones and biflavones from Selaginella moellendorffii Hieron".FITOTERAPIA 81.4(2010):253-258.
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