Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr.

doi:10.1021/jf903434h

	Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr.
	Yan, Xiao-Hui 1,2; Chen, Jia 1,2; Di, Ying-Tong1 ; Fang, Xin 1; Dong, Jia-Hong 3; Sang, Peng 3; Wang, Yue-Hu1 ; He, Hong-Ping 1; Zhang, Zhong-Kai 3; Hao, Xiao-Jiang1
	2010-02-10
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	0021-8561
卷号	58 期号:3 页码:1572-1577
摘要	Two new quassinoids, javanicolide E (1) and javanicolide F (2), along with fifteen known C-20 quassinoids were isolated from the seeds of Brucea javanica (L.) Merr. The antitobacco, mosaic virus (TMV) activity of these quassinoids was screened by the conventional half-leaf and leaf-disk method along with Western blot analysis. All of the seventeen quassinoids showed potent anti-TMV activity. Among them, eight compounds, brusatol (3), bruceine B (4), bruceoside B (5), yadanzioside 1 (6), yaclanzioside L (7), bruceine D (8), yadanziolide A (9), and aglycone of yadanziolide D (17), showed strong antiviral activities, with IC(50) values in the range of 3.42-5.66 mu M, and were much more effective than the positive control, ningnanmycin (IC(50) = 117.3 mu M). The antiviral structure-activity relationships of quassinoids against TMV were also discussed.
关键词	Tobacco Mosaic Virus (Tmv) Brucea Javanica (L.) Merr. Quassinoids Structure-activity Relationship (Sar)
学科领域	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
DOI	10.1021/jf903434h
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000274269000028
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4944
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Yunnan Acad Agr Sci, Kunming 650023, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yan, Xiao-Hui,Chen, Jia,Di, Ying-Tong,et al. Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr.[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2010,58(3):1572-1577.
APA	Yan, Xiao-Hui.,Chen, Jia.,Di, Ying-Tong.,Fang, Xin.,Dong, Jia-Hong.,...&Hao, Xiao-Jiang.(2010).Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr..JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,58(3),1572-1577.
MLA	Yan, Xiao-Hui,et al."Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr.".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 58.3(2010):1572-1577.

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