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题名: Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr.
作者: Yan, Xiao-Hui1, 2; Chen, Jia1, 2; Di, Ying-Tong1; Fang, Xin1; Dong, Jia-Hong3; Sang, Peng3; Wang, Yue-Hu1; He, Hong-Ping1; Zhang, Zhong-Kai3; null(郝小江)1
刊名: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
关键词: Tobacco mosaic virus (TMV) ; Brucea javanica (L.) Merr. ; quassinoids ; structure-activity relationship (SAR)
英文摘要: Two new quassinoids, javanicolide E (1) and javanicolide F (2), along with fifteen known C-20 quassinoids were isolated from the seeds of Brucea javanica (L.) Merr. The antitobacco, mosaic virus (TMV) activity of these quassinoids was screened by the conventional half-leaf and leaf-disk method along with Western blot analysis. All of the seventeen quassinoids showed potent anti-TMV activity. Among them, eight compounds, brusatol (3), bruceine B (4), bruceoside B (5), yadanzioside 1 (6), yaclanzioside L (7), bruceine D (8), yadanziolide A (9), and aglycone of yadanziolide D (17), showed strong antiviral activities, with IC(50) values in the range of 3.42-5.66 mu M, and were much more effective than the positive control, ningnanmycin (IC(50) = 117.3 mu M). The antiviral structure-activity relationships of quassinoids against TMV were also discussed.
出版日期: 2010-02-10
卷号: 58, 期号:3, 页码:1572-1577
DOI标识: 10.1021/jf903434h
语种: 英语
收录类别: SCI ; IC
学科分类: Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology
ISSN号: 0021-8561
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4944
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Yunnan Acad Agr Sci, Kunming 650023, Yunnan, Peoples R China

Recommended Citation:
Yan, XH; Chen, J; Di, YT; Fang, X; Dong, JH; Sang, P; Wang, YH; He, HP; Zhang, ZK; Hao, XJ.Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr.,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2010,58(3):1572-1577
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