A petrol ether extract of the roots of Onosma paniculatum induces cell death in a caspase dependent manner
Rinner, Beate2; Kretschmer, Nadine1; Knausz, Heike2; Mayer, Andrea2; Boechzelt, Herbert3; Hao, Xiao-Jiang4; Heubl, Guenther5; Efferth, Thomas6; Schaider, Helmut7,8; Bauer, Rudolf1
Corresponding AuthorBauer, R, Karl Franzens Univ Graz, Dept Pharmacognosy, Inst Pharmaceut Sci, Univ Pl 4, A-8010 Graz, Austria
2010-05-27
Source PublicationJOURNAL OF ETHNOPHARMACOLOGY
ISSN0378-8741
Volume129Issue:2Pages:182-188
AbstractAim of the study: Traditional Chinese medicine (TCM) has become very popular in Western countries during the last years. Zicao, a remedy of TCM, has been traditionally used to treat cancer, and, its main constituents, naphthoquinones, have been reported to possess antitumor activity (Chen et al., 2002; Papageorgiou et al., 1999). Here, we prepared extracts of different polarities of Onosma paniculatum Bur. & Franch., a plant which is amongst others used as Zicao, but, much less investigated. The extracts were analyzed concerning their growth inhibitory and apoptosis-inducing activity in various tumor cells.
KeywordOnosma Paniculatum Zicao Cancer Cell Cycle Caspase-3
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
DOI10.1016/j.jep.2010.02.006
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000278651300005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4916
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Karl Franzens Univ Graz, Dept Pharmacognosy, Inst Pharmaceut Sci, A-8010 Graz, Austria
2.Med Univ Graz, Core Facil Flow Cytometry, Med Res Ctr, A-8010 Graz, Austria
3.Joanneum Res Forsch Gesell mbH, A-8010 Graz, Austria
4.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
5.LMU Dept Biol Systemat Bot & Mykol, D-80638 Munich, Germany
6.Johannes Gutenberg Univ Mainz, Dept Pharmaceut Biol, Inst Pharm, D-55099 Mainz, Germany
7.Med Univ Graz, Dept Dermatol, Canc Biol Unit, A-8036 Graz, Austria
8.Med Univ Graz, Med Res Ctr, A-8036 Graz, Austria
Recommended Citation
GB/T 7714
Rinner, Beate,Kretschmer, Nadine,Knausz, Heike,et al. A petrol ether extract of the roots of Onosma paniculatum induces cell death in a caspase dependent manner[J]. JOURNAL OF ETHNOPHARMACOLOGY,2010,129(2):182-188.
APA Rinner, Beate.,Kretschmer, Nadine.,Knausz, Heike.,Mayer, Andrea.,Boechzelt, Herbert.,...&Bauer, Rudolf.(2010).A petrol ether extract of the roots of Onosma paniculatum induces cell death in a caspase dependent manner.JOURNAL OF ETHNOPHARMACOLOGY,129(2),182-188.
MLA Rinner, Beate,et al."A petrol ether extract of the roots of Onosma paniculatum induces cell death in a caspase dependent manner".JOURNAL OF ETHNOPHARMACOLOGY 129.2(2010):182-188.
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