| Biochemical, haematological and histopathological studies of extract of Ageratum conyzoides L. in Sprague Dawley rats | |
| Adebayo, Abiodun Humphrey1,2; Zeng, Guang-Zhi1; Fan, Jun-Ting1; Ji, Chang-Jiu1; He, Wen-Jun1; Xu, Jun-Ju1; Zhang, Yu-Mei1; Akindahunsi, Afolabi Akintunde3; Kela, Roseline4; Tan, Ning-Hua1 | |
| 2010-11-04 | |
| 发表期刊 | JOURNAL OF MEDICINAL PLANTS RESEARCH
 |
| ISSN | 1996-0875 |
| 卷号 | 4期号:21页码:2264-2272 |
| 摘要 | This study was conducted to evaluate the safety potential of the leaf extract of Ageratum conyzoides Linnaeus in Sprague Dawley (SD) rats using biochemical, haematological and histological indices of toxicity. Four groups of seven male SD rats per group were used for the study. To group A was administered 0.25% CMC-Na/kg body weight and was used as the control group, while groups B, C and D were respectively administered with 500, 1000 and 1500 mg/kg body weight of the ethanolic leaf extract of A. conyzoides by gastric intubation for 14 days. Animals were subsequently anaesthetized, blood samples were collected for biochemical and haematological assays; organs were isolated and weighed, while the liver, kidney and spleen were processed for histopathological studies. Aspartate amino transferase, lactate dehydrogenase, creatine kinase and alkaline phosphatase were significantly (p < 0.05) reduced in the groups treated with 1000 and 1500 mg/kg body weight of the extract. Furthermore, there was a significant (p < 0.05) elevation in white blood cell count, mean platelet volume and % platelet distribution width. Histopathological studies indicated various degrees of hepatocellular necrosis in all the treated groups accompanied by significant increases in the weight of liver and spleen. The results showed that the ethanolic leaf extract of A. conyzoides significantly alters the biomarkers of cardiac and skeletal muscle disorders, and higher doses could induce liver cell injury. |
| 关键词 | Ageratum Conyzoides Asteraceae Liver Markers Histopathological Study Toxicological Study |
| 学科领域 | Chemistry, Medicinal |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000285689600015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/4912 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Covenant Univ, Dept Biol Sci, Coll Sci & Technol, Ota, Ogun State, Nigeria 3.Fed Univ Technol Akure, Dept Biochem, Akure, Ondo State, Nigeria 4.Energy Commiss Nigeria, Garki Cenral Area, Abuja, FCT, Nigeria |
| 推荐引用方式 GB/T 7714 | Adebayo, Abiodun Humphrey,Zeng, Guang-Zhi,Fan, Jun-Ting,et al. Biochemical, haematological and histopathological studies of extract of Ageratum conyzoides L. in Sprague Dawley rats[J]. JOURNAL OF MEDICINAL PLANTS RESEARCH,2010,4(21):2264-2272. |
| APA | Adebayo, Abiodun Humphrey.,Zeng, Guang-Zhi.,Fan, Jun-Ting.,Ji, Chang-Jiu.,He, Wen-Jun.,...&Tan, Ning-Hua.(2010).Biochemical, haematological and histopathological studies of extract of Ageratum conyzoides L. in Sprague Dawley rats.JOURNAL OF MEDICINAL PLANTS RESEARCH,4(21),2264-2272. |
| MLA | Adebayo, Abiodun Humphrey,et al."Biochemical, haematological and histopathological studies of extract of Ageratum conyzoides L. in Sprague Dawley rats".JOURNAL OF MEDICINAL PLANTS RESEARCH 4.21(2010):2264-2272. |
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