Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida

doi:10.1021/np9003855

	Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida
	Nian, Yin1,2 ; Zhang, Yan-Li 3; Chen, Jian-Chao 1; Lu, Lu 1,2; Qiu, Ming-Hua1 ; Qing, Chen 3
	2010-02-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	73 期号:2 页码:93-98
摘要	Seven new 9,19-cycloartane triterpene glycosides. 25-O-acetylcimigenol-3-O-[2'-O-(E)-2-butenoyl]-beta-D-xylopyranoside (1), 25-O-acetylcimigenol-3-O-[4'-O-(E)-2-butenoyl]-beta-D-xylopyranoside (2), 25-O-acetylcimigenol-3-O-[3'-O-acetyl]-beta-D-xylopyranoside (3), 25-O-acetylcimigenol-3-O-[4'-O-acetyl]-beta-D-xylopyranoside (4), 25-O-acetyl-12 beta-acetoxycimingenol-3-O-beta-D-xylopyranoside (5), 3'-O-acetylactein (6). and 3'-O-acetyl-23-epi-26-deoxyactein (7), together with eight known compounds (8-15), were isolated from the roots of Cimicifuga fetida. Their structures were established by spectroscopic and chemical methods. Most of these compounds Showed more selective and higher cytotoxicity against the human HepG2 cell line than against the MCF7, HT29. and MKN28 cell lines. compounds 2, 3, and 7 exhibited significant cytotoxicity against HepG2 cells, with IC(50) values of 1.29, 0.71, and 1.41 mu M, respectively.
关键词	Cinerascens Tetranortriterpenoids
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np9003855
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000274803600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4898
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming 650031, Peoples R China
推荐引用方式 GB/T 7714	Nian, Yin,Zhang, Yan-Li,Chen, Jian-Chao,et al. Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(2):93-98.
APA	Nian, Yin,Zhang, Yan-Li,Chen, Jian-Chao,Lu, Lu,Qiu, Ming-Hua,&Qing, Chen.(2010).Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida.JOURNAL OF NATURAL PRODUCTS,73(2),93-98.
MLA	Nian, Yin,et al."Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida".JOURNAL OF NATURAL PRODUCTS 73.2(2010):93-98.

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