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题名: Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida
作者: Nian, Yin1, 2; Zhang, Yan-Li3; Chen, Jian-Chao1; Lu, Lu1, 2; null(邱明华)1; Qing, Chen3
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: CINERASCENS ; TETRANORTRITERPENOIDS
英文摘要: Seven new 9,19-cycloartane triterpene glycosides. 25-O-acetylcimigenol-3-O-[2'-O-(E)-2-butenoyl]-beta-D-xylopyranoside (1), 25-O-acetylcimigenol-3-O-[4'-O-(E)-2-butenoyl]-beta-D-xylopyranoside (2), 25-O-acetylcimigenol-3-O-[3'-O-acetyl]-beta-D-xylopyranoside (3), 25-O-acetylcimigenol-3-O-[4'-O-acetyl]-beta-D-xylopyranoside (4), 25-O-acetyl-12 beta-acetoxycimingenol-3-O-beta-D-xylopyranoside (5), 3'-O-acetylactein (6). and 3'-O-acetyl-23-epi-26-deoxyactein (7), together with eight known compounds (8-15), were isolated from the roots of Cimicifuga fetida. Their structures were established by spectroscopic and chemical methods. Most of these compounds Showed more selective and higher cytotoxicity against the human HepG2 cell line than against the MCF7, HT29. and MKN28 cell lines. compounds 2, 3, and 7 exhibited significant cytotoxicity against HepG2 cells, with IC(50) values of 1.29, 0.71, and 1.41 mu M, respectively.
出版日期: 2010-02-01
卷号: 73, 期号:2, 页码:93-98
DOI标识: 10.1021/np9003855
语种: 英语
ISSN号: 0163-3864
资助信息: Foundation of the Key State Laboratory of Phytochemistry [P2008-ZZ05]; National Natural Science Foundation of China [30772636]; National Science Foundation of Yunnan Province [2005C0010Z]
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4898
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming 650031, Peoples R China

Recommended Citation:
Nian, Y; Zhang, YL; Chen, JC; Lu, L; Qiu, MH; Qing, C.Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida,JOURNAL OF NATURAL PRODUCTS,2010,73(2):93-98
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