Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida
Nian, Yin1,2; Zhang, Yan-Li3; Chen, Jian-Chao1; Lu, Lu1,2; Qiu, Ming-Hua1; Qing, Chen3
2010-02-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号73期号:2页码:93-98
摘要Seven new 9,19-cycloartane triterpene glycosides. 25-O-acetylcimigenol-3-O-[2'-O-(E)-2-butenoyl]-beta-D-xylopyranoside (1), 25-O-acetylcimigenol-3-O-[4'-O-(E)-2-butenoyl]-beta-D-xylopyranoside (2), 25-O-acetylcimigenol-3-O-[3'-O-acetyl]-beta-D-xylopyranoside (3), 25-O-acetylcimigenol-3-O-[4'-O-acetyl]-beta-D-xylopyranoside (4), 25-O-acetyl-12 beta-acetoxycimingenol-3-O-beta-D-xylopyranoside (5), 3'-O-acetylactein (6). and 3'-O-acetyl-23-epi-26-deoxyactein (7), together with eight known compounds (8-15), were isolated from the roots of Cimicifuga fetida. Their structures were established by spectroscopic and chemical methods. Most of these compounds Showed more selective and higher cytotoxicity against the human HepG2 cell line than against the MCF7, HT29. and MKN28 cell lines. compounds 2, 3, and 7 exhibited significant cytotoxicity against HepG2 cells, with IC(50) values of 1.29, 0.71, and 1.41 mu M, respectively.
关键词Cinerascens Tetranortriterpenoids
资助信息Foundation of the Key State Laboratory of Phytochemistry [P2008-ZZ05]; National Natural Science Foundation of China [30772636]; National Science Foundation of Yunnan Province [2005C0010Z]
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np9003855
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000274803600001
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4898
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming 650031, Peoples R China
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GB/T 7714
Nian, Yin,Zhang, Yan-Li,Chen, Jian-Chao,et al. Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(2):93-98.
APA Nian, Yin,Zhang, Yan-Li,Chen, Jian-Chao,Lu, Lu,Qiu, Ming-Hua,&Qing, Chen.(2010).Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida.JOURNAL OF NATURAL PRODUCTS,73(2),93-98.
MLA Nian, Yin,et al."Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida".JOURNAL OF NATURAL PRODUCTS 73.2(2010):93-98.
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