Cytotoxic Polyphenols from the Marine-Derived Fungus Penicillium expansum
Lu, Zhenyu2; Zhu, Huajie3; Fu, Peng2; Wang, Yi2; Zhang, Zhihua1; Lin, Haipeng1; Liu, Peipei2; Zhuang, Yibin2; Hong, Kui1; Zhu, Weiming2
2010-05-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume73Issue:5Pages:911-914
AbstractTwo new polyphenols containing both phenolic bisabolane sesquiterpenoid and diphenyl ether units, expansols A (1) and B (2), and two new phenolic bisabolane sesquiterpenoids, (S)-(+)-11-dehydrosydonic acid (3) and (7S,11S)-(+)12-acetoxysydonic acid (4), along with two known compounds, (S)-(+)-sydonic acid (5) and diorcinol (6), were isolated from the metabolites of the marine-derived fungus Penicillium expansum 091006 endogenous with the mangrove plant Excoecaria agallocha. On the basis of spectroscopic analysis, chemical transformation, and theoretical calculation, the structures of 1-4 were elucidated as (S)-(+)-2[3-hydroxy-4-(2- methoxy-6-methylheptan-2-yl)benzyl]-5-(3-hydroxy-5-methylphenoxy)-3-methylphenol, S-(+)-2-[3-hydroxy-4-(2-hydroxy-6-methylheptan-2-yl)benzyl]-5-(3-hydroxy-5-methylphenoxy)-3-methylphenol, (S)-(+)-3-hydroxy-4-(2-hydroxy-6-methylhept-6-en-2-yl)benzoic acid, and 4-[(2S,6S)-7-acetoxy-2-hydroxy-6-methylheptan-2-yl]-3-hydroxybenzoic acid, respectively. Expansol A (1) exhibited moderate cytotoxicity against the HL-60 cell line with an IC(50) value of 15.7 mu M, and expansol B (2) inhibited the proliferation of A549 and HL-60 cells with IC(50) values of 1.9 and 5.4 mu M, respectively.
KeywordKaurene Diterpenoids Taihangensis Constituents Leucantha
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np100059m
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000278080900022
Citation statistics
Cited Times:52[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4894
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Trop Agr Sci, Inst Trop Biol Sci & Biotechnol, Haikou 571101, Peoples R China
2.Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources, Kunming Inst Bot, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Lu, Zhenyu,Zhu, Huajie,Fu, Peng,et al. Cytotoxic Polyphenols from the Marine-Derived Fungus Penicillium expansum[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(5):911-914.
APA Lu, Zhenyu.,Zhu, Huajie.,Fu, Peng.,Wang, Yi.,Zhang, Zhihua.,...&Zhu, Weiming.(2010).Cytotoxic Polyphenols from the Marine-Derived Fungus Penicillium expansum.JOURNAL OF NATURAL PRODUCTS,73(5),911-914.
MLA Lu, Zhenyu,et al."Cytotoxic Polyphenols from the Marine-Derived Fungus Penicillium expansum".JOURNAL OF NATURAL PRODUCTS 73.5(2010):911-914.
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