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题名: Cytotoxic Polyphenols from the Marine-Derived Fungus Penicillium expansum
作者: Lu, Zhenyu2; Zhu, Huajie3; Fu, Peng2; Wang, Yi2; Zhang, Zhihua1; Lin, Haipeng1; Liu, Peipei2; Zhuang, Yibin2; Hong, Kui1; Zhu, Weiming2
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: KAURENE DITERPENOIDS ; TAIHANGENSIS ; CONSTITUENTS ; LEUCANTHA
英文摘要: Two new polyphenols containing both phenolic bisabolane sesquiterpenoid and diphenyl ether units, expansols A (1) and B (2), and two new phenolic bisabolane sesquiterpenoids, (S)-(+)-11-dehydrosydonic acid (3) and (7S,11S)-(+)12-acetoxysydonic acid (4), along with two known compounds, (S)-(+)-sydonic acid (5) and diorcinol (6), were isolated from the metabolites of the marine-derived fungus Penicillium expansum 091006 endogenous with the mangrove plant Excoecaria agallocha. On the basis of spectroscopic analysis, chemical transformation, and theoretical calculation, the structures of 1-4 were elucidated as (S)-(+)-2[3-hydroxy-4-(2- methoxy-6-methylheptan-2-yl)benzyl]-5-(3-hydroxy-5-methylphenoxy)-3-methylphenol, S-(+)-2-[3-hydroxy-4-(2-hydroxy-6-methylheptan-2-yl)benzyl]-5-(3-hydroxy-5-methylphenoxy)-3-methylphenol, (S)-(+)-3-hydroxy-4-(2-hydroxy-6-methylhept-6-en-2-yl)benzoic acid, and 4-[(2S,6S)-7-acetoxy-2-hydroxy-6-methylheptan-2-yl]-3-hydroxybenzoic acid, respectively. Expansol A (1) exhibited moderate cytotoxicity against the HL-60 cell line with an IC(50) value of 15.7 mu M, and expansol B (2) inhibited the proliferation of A549 and HL-60 cells with IC(50) values of 1.9 and 5.4 mu M, respectively.
出版日期: 2010-05-01
卷号: 73, 期号:5, 页码:911-914
DOI标识: 10.1021/np100059m
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4894
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Trop Agr Sci, Inst Trop Biol Sci & Biotechnol, Haikou 571101, Peoples R China
2.Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources, Kunming Inst Bot, Kunming 650204, Peoples R China

Recommended Citation:
Lu, ZY; Zhu, HJ; Fu, P; Wang, Y; Zhang, ZH; Lin, HP; Liu, PP; Zhuang, YB; Hong, K; Zhu, WM.Cytotoxic Polyphenols from the Marine-Derived Fungus Penicillium expansum,JOURNAL OF NATURAL PRODUCTS,2010,73(5):911-914
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