Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity
Shi, Li-Shian1; Liao, Yu-Ren1; Su, Ming-Jai2; Lee, An-Sheng2; Kuo, Ping-Chung1; Damu, Amooru G.1; Kuo, Sheng-Chu3; Sun, Han-Dong5; Lee, Kuo-Hsiung6; Wu, Tian-Shung1,4
2010-07-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号73期号:7页码:1214-1222
摘要An ethanolic extract of Antiaris toxicaria trunk hark showed potent in vitro cardiotonic effect on isolated guinea pig atria. Bioassay-guided fractionation of the extract led to identification of nine new cardiac glycosides (1-9, named antiarosides A-1), antiarotoxinin A (10), and 18 known compounds. Their structures were established using MS and NMR spectroscopic studies, including homonuclear and heteronuclear correlation experiments. The ability of these cardiotonic compounds to produce positive inotropic action and their safety indexes were examined in comparison with those of ouabain, a classical inhibitor of Na(+)/K(+)-ATPase. Malayoside (23) was nearly equipotent and had a similar safety index to ouabain in guinea pig atria. However, the maximal positive inotropic effect and safety index of 23 in papillary muscle were better than those of ouabain. An electrophysiological recording showed that 23 inhibited the sod urn pump current in a concentration-dependent manlier.
关键词Alstonia-scholaris Leaves Culture Pichon
资助信息National Science Council, Taiwan, Republic of China ; NIH [CA-17625]
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np9005212
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000280140500005
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4886
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan
2.Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan
3.China Med Univ, Grad Inst Pharmaceut Chem, Taichung 401, Taiwan
4.China Med Univ, Dept Pharm, Taichung 401, Taiwan
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
6.Univ N Carolina, Nat Prod Res Labs, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USA
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Shi, Li-Shian,Liao, Yu-Ren,Su, Ming-Jai,et al. Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(7):1214-1222.
APA Shi, Li-Shian.,Liao, Yu-Ren.,Su, Ming-Jai.,Lee, An-Sheng.,Kuo, Ping-Chung.,...&Wu, Tian-Shung.(2010).Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity.JOURNAL OF NATURAL PRODUCTS,73(7),1214-1222.
MLA Shi, Li-Shian,et al."Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity".JOURNAL OF NATURAL PRODUCTS 73.7(2010):1214-1222.
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