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题名: Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity
作者: Shi, Li-Shian1; Liao, Yu-Ren1; Su, Ming-Jai2; Lee, An-Sheng2; Kuo, Ping-Chung1; Damu, Amooru G.1; Kuo, Sheng-Chu3; null(孙汉董)5; Lee, Kuo-Hsiung6; Wu, Tian-Shung1, 4
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: ALSTONIA-SCHOLARIS ; LEAVES ; CULTURE ; PICHON
英文摘要: An ethanolic extract of Antiaris toxicaria trunk hark showed potent in vitro cardiotonic effect on isolated guinea pig atria. Bioassay-guided fractionation of the extract led to identification of nine new cardiac glycosides (1-9, named antiarosides A-1), antiarotoxinin A (10), and 18 known compounds. Their structures were established using MS and NMR spectroscopic studies, including homonuclear and heteronuclear correlation experiments. The ability of these cardiotonic compounds to produce positive inotropic action and their safety indexes were examined in comparison with those of ouabain, a classical inhibitor of Na(+)/K(+)-ATPase. Malayoside (23) was nearly equipotent and had a similar safety index to ouabain in guinea pig atria. However, the maximal positive inotropic effect and safety index of 23 in papillary muscle were better than those of ouabain. An electrophysiological recording showed that 23 inhibited the sod urn pump current in a concentration-dependent manlier.
出版日期: 2010-07-01
卷号: 73, 期号:7, 页码:1214-1222
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4886
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan
2.Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan
3.China Med Univ, Grad Inst Pharmaceut Chem, Taichung 401, Taiwan
4.China Med Univ, Dept Pharm, Taichung 401, Taiwan
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
6.Univ N Carolina, Nat Prod Res Labs, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

Recommended Citation:
Shi, LS; Liao, YR; Su, MJ; Lee, AS; Kuo, PC; Damu, AG; Kuo, SC; Sun, HD; Lee, KH; Wu, TS.Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity,JOURNAL OF NATURAL PRODUCTS,2010,73(7):1214-1222
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