Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity
Shi, Li-Shian1; Liao, Yu-Ren1; Su, Ming-Jai2; Lee, An-Sheng2; Kuo, Ping-Chung1; Damu, Amooru G.1; Kuo, Sheng-Chu3; Sun, Han-Dong5; Lee, Kuo-Hsiung6; Wu, Tian-Shung1,4
Corresponding AuthorWu, TS, Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan
2010-07-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume73Issue:7Pages:1214-1222
AbstractAn ethanolic extract of Antiaris toxicaria trunk hark showed potent in vitro cardiotonic effect on isolated guinea pig atria. Bioassay-guided fractionation of the extract led to identification of nine new cardiac glycosides (1-9, named antiarosides A-1), antiarotoxinin A (10), and 18 known compounds. Their structures were established using MS and NMR spectroscopic studies, including homonuclear and heteronuclear correlation experiments. The ability of these cardiotonic compounds to produce positive inotropic action and their safety indexes were examined in comparison with those of ouabain, a classical inhibitor of Na(+)/K(+)-ATPase. Malayoside (23) was nearly equipotent and had a similar safety index to ouabain in guinea pig atria. However, the maximal positive inotropic effect and safety index of 23 in papillary muscle were better than those of ouabain. An electrophysiological recording showed that 23 inhibited the sod urn pump current in a concentration-dependent manlier.
KeywordAlstonia-scholaris Leaves Culture Pichon
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np9005212
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000280140500005
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4886
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan
2.Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan
3.China Med Univ, Grad Inst Pharmaceut Chem, Taichung 401, Taiwan
4.China Med Univ, Dept Pharm, Taichung 401, Taiwan
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
6.Univ N Carolina, Nat Prod Res Labs, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USA
Recommended Citation
GB/T 7714
Shi, Li-Shian,Liao, Yu-Ren,Su, Ming-Jai,et al. Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(7):1214-1222.
APA Shi, Li-Shian.,Liao, Yu-Ren.,Su, Ming-Jai.,Lee, An-Sheng.,Kuo, Ping-Chung.,...&Wu, Tian-Shung.(2010).Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity.JOURNAL OF NATURAL PRODUCTS,73(7),1214-1222.
MLA Shi, Li-Shian,et al."Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity".JOURNAL OF NATURAL PRODUCTS 73.7(2010):1214-1222.
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