Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata

doi:10.1021/np900309p

	Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata
	Zhu, Feng 1,2; Di, Ying-Tong1 ; Liu, Ling-Li 1; Zhang, Qiang 1; Fang, Xin 1; Yang, Ting-Quan 1; Hao, Xiao-Jiang1 ; He, Hong-Ping 1
通讯作者	Hao, XJ, Chinese Acad Sci, Kunming Inst Bot, Stale Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
	2010-02-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	73 期号:2 页码:233-236
摘要	Seven new neoclerodane diterpenoids, scutebatas A-G (1-7), have been isolated front Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their Structures Were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1. Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 mu M.
关键词	Glykoside Und Aglykone Dart Poisons Lesch Arrow
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np900309p
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000274803600028
引用统计	被引频次：37[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4884
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Stale Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Feng,Di, Ying-Tong,Liu, Ling-Li,et al. Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(2):233-236.
APA	Zhu, Feng.,Di, Ying-Tong.,Liu, Ling-Li.,Zhang, Qiang.,Fang, Xin.,...&He, Hong-Ping.(2010).Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata.JOURNAL OF NATURAL PRODUCTS,73(2),233-236.
MLA	Zhu, Feng,et al."Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata".JOURNAL OF NATURAL PRODUCTS 73.2(2010):233-236.

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