Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata
Zhu, Feng1,2; Di, Ying-Tong1; Liu, Ling-Li1; Zhang, Qiang1; Fang, Xin1; Yang, Ting-Quan1; Hao, Xiao-Jiang1; He, Hong-Ping1
2010-02-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号73期号:2页码:233-236
摘要Seven new neoclerodane diterpenoids, scutebatas A-G (1-7), have been isolated front Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their Structures Were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1. Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 mu M.
关键词Glykoside Und Aglykone Dart Poisons Lesch Arrow
资助信息Ministry of Science and Technology of China [2009CB940900, 2009CB522300]; Natural Science Funding of Yunnan Province [2009CD112]
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4884
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Stale Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Zhu, Feng,Di, Ying-Tong,Liu, Ling-Li,et al. Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(2):233-236.
APA Zhu, Feng.,Di, Ying-Tong.,Liu, Ling-Li.,Zhang, Qiang.,Fang, Xin.,...&He, Hong-Ping.(2010).Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata.JOURNAL OF NATURAL PRODUCTS,73(2),233-236.
MLA Zhu, Feng,et al."Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata".JOURNAL OF NATURAL PRODUCTS 73.2(2010):233-236.
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