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题名: Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata
作者: Zhu, Feng1, 2; Di, Ying-Tong1; Liu, Ling-Li1; Zhang, Qiang1; Fang, Xin1; Yang, Ting-Quan1; null(郝小江)1; He, Hong-Ping1
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: GLYKOSIDE UND AGLYKONE ; DART POISONS ; LESCH ; ARROW
英文摘要: Seven new neoclerodane diterpenoids, scutebatas A-G (1-7), have been isolated front Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their Structures Were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1. Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 mu M.
出版日期: 2010-02-01
卷号: 73, 期号:2, 页码:233-236
DOI标识: 10.1021/np900309p
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4884
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Stale Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

Recommended Citation:
Zhu, F; Di, YT; Liu, LL; Zhang, Q; Fang, X; Yang, TQ; Hao, XJ; He, HP.Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata,JOURNAL OF NATURAL PRODUCTS,2010,73(2):233-236
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