中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Isolation and characterization of cytotoxic cyclotides from Viola tricolor
作者: Tang, Jun1, 3; Wang, Conan K.2; Pan, Xulin1; Yan, He1, 3; Zeng, Guangzhi1; Xu, Wenyan1, 3; He, Wenjun1, 3; Daly, Norelle L.2; Craik, David J.2; Tan, Ninghua1
刊名: PEPTIDES
关键词: Cyclotides ; Viola tricolor ; Cytotoxic activity ; vitri B-F ; varv Hm ; varv He
英文摘要: Many plants of the Violaceae plant family have been used in traditional remedies, and these plants often contain cyclotides, a particular type of plant cyclopeptide that is distinguished by a cyclic cystine knot motif. In general, bioactive plant cyclopeptides are interesting candidates for drug development. In the current study, a suite of 14 cyclotides, which includes seven novel cyclotides [vitri B, C, D, E, F, vary Hm, and He], together with seven known cyclotides [vary A, D, E, F, H, vitri A, and cycloviolacin O2], was isolated from Viola tricolor, a common flower. A chromatography-based method was used to isolate the cyclotides, which were characterized using tandem mass spectrometry and NMR spectroscopy. Several of the cyclotides showed cytotoxic activities against five cancer cell lines, U251, MDA-MB-231, A549, DU145, and BEL-7402. Three cyclotides, vitri A, vitri F, and cycloviolacin O2, were the most cytotoxic. The cytotoxic activity of the cyclotides did not correlate well with their hemolytic activity, indicating that different interactions, most likely with membranes, are involved for cytotoxic and hemolytic activities. Homology modeling of the structures was used in deriving structure-activity relationships. (C) 2010 Elsevier Inc. All rights reserved.
出版日期: 2010-08-01
卷号: 31, 期号:8, 页码:1434-1440
DOI标识: 10.1016/j.peptides.2010.05.004
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Pharmacology & Pharmacy
ISSN号: 0196-9781
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4868
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
201202130060.pdf(1079KB)----开放获取--View Download

作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Tang, J; Wang, CK; Pan, XL; Yan, H; Zeng, GZ; Xu, WY; He, WJ; Daly, NL; Craik, DJ; Tan, NH.Isolation and characterization of cytotoxic cyclotides from Viola tricolor,PEPTIDES,2010,31(8):1434-1440
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Tang, Jun]'s Articles
[Wang, Conan K.]'s Articles
[Pan, Xulin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Tang, Jun]‘s Articles
[Wang, Conan K.]‘s Articles
[Pan, Xulin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 201202130060.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace