Bioactive compounds from Rumex plants
Liang, Heng-Xing1,3; Dai, Huan-Qin2; Fu, Hai-An4,5; Dong, Xiao-Ping3; Adebayo, Abiodun Humphrey1; Zhang, Li-Xin2; Cheng, Yong-Xian1
2010-12-17
发表期刊PHYTOCHEMISTRY LETTERS
ISSN1874-3900
卷号3期号:4页码:181-184
摘要Two new naphthalene acylglucosides, rumexneposides A (1) and B (2), together with 12 known compounds (3-14), were isolated from the roots of Rumex nepalensis. Their structures were established by chemical and spectroscopic methods. The biological activities of compounds 1-14 as well as an additional 11 compounds previously isolated from R. nepalensis and Rumex hastatus (15-25) were evaluated against Mycobacterium tuberculosis, para-aminobenzoic acid (pAba) pathway, and a panel of human cancer cell lines. The results showed that compound 15 was the most active against M. tuberculosis with an MIC value of 2.85 mu M similar to that of isoniazid. Compound 5 could inhibit pAba synthetic pathway with an MIC value of 12.6 mu M, comparable to that of positive control abyssomicin C, representing a new example of the rare pAba pathway inhibitors. (C) 2010 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
关键词Rumex Nepalensis Rumex Hastatus Polygonaceae Rumexneposides a And b Anti-tuberculosis Paba Pathway Inhibitor Cytotoxicity
资助信息National Natural Science Foundation of China [20972165]; Chinese Academy of Sciences ; Ministry of Science and Technology of China [2008ZX09401-004]; "Talent Scholarship of Yunnan Youth" from Yunnan Province [2007PY01-48]
学科领域Biochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytol.2010.05.005
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000287849600003
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4858
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China
3.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
4.Emory Univ, Dept Pharmacol, Sch Med, Atlanta, GA 30322 USA
5.Emory Chem Biol Discovery Ctr, Atlanta, GA 30322 USA
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GB/T 7714
Liang, Heng-Xing,Dai, Huan-Qin,Fu, Hai-An,et al. Bioactive compounds from Rumex plants[J]. PHYTOCHEMISTRY LETTERS,2010,3(4):181-184.
APA Liang, Heng-Xing.,Dai, Huan-Qin.,Fu, Hai-An.,Dong, Xiao-Ping.,Adebayo, Abiodun Humphrey.,...&Cheng, Yong-Xian.(2010).Bioactive compounds from Rumex plants.PHYTOCHEMISTRY LETTERS,3(4),181-184.
MLA Liang, Heng-Xing,et al."Bioactive compounds from Rumex plants".PHYTOCHEMISTRY LETTERS 3.4(2010):181-184.
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