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题名: New Polyketides from Endophytic Diaporthe sp XZ-07
作者: Yuan, Lin1, 2; Lin, Xiang3; Zhao, Pei-Ji1; Ma, Juan1; Huang, Yao-Jian2; Shen, Yue-Mao1, 2
刊名: HELVETICA CHIMICA ACTA
关键词: STREPTOMYCES-SP ; OIDIOLACTONE-C ; METABOLITES ; OIDIODENDRON ; ACID
英文摘要: Four new polyketides, namely rel-(2R,3S,4R,5R)-4-ethyltetrahydro-3-methyl-5-propylfuran-2,3-diol (1), methyl 5-[(1R)-1-hydroxyethyl]-gamma-oxofuran-2-butanoate (2), butyl 5-[(1R)-1-hydroxyethyl]-gamma-oxofuran-2-butanoate (3), and 3,4-dihydro-5'-[(1R)-1-hydroxyethyl][2,2'-bifuran]-5(2H)-one (4), together with three known ones, 5-[(1R)-1-hydroxethyl)-gamma-oxofuran-2-butanoic acid (5), phomopsolide B (6), and (2S,3S)-3,6-dihydro-6-oxo-2-[(1E)-2-{(4S,5S)-2,2,5-trimethyl-1,3-dioxolan-4-yl]ethenyl)-2H-pyran-3-yl (2E)-2-methylbut-2-enoate (7), were isolated from the submerged cultures of the endophytic fungal strain Diaporthe sp. XZ-07 of Camptotheca acuminate. The structures of the new compounds were established by 1D- and 2D-NMR and MS data and by Mosher's method. Compound 6 significantly inhibited the growth of human-tumor HeLa cells with an IC(50) of 5.7 mu g/ml by the MTT assay (MTT = 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide).
出版日期: 2009
卷号: 92, 期号:6, 页码:1184-1190
语种: 英语
ISSN号: 0018-019X
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4850
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Xiamen Univ, Sch Life Sci, Xiamen 361005, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Yuan, L; Lin, X; Zhao, PJ; Ma, J; Huang, YJ; Shen, YM.New Polyketides from Endophytic Diaporthe sp XZ-07,HELVETICA CHIMICA ACTA,2009,92(6):1184-1190
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