New Polyketides from Endophytic Diaporthe sp XZ-07
Yuan, Lin1,2; Lin, Xiang3; Zhao, Pei-Ji1; Ma, Juan1; Huang, Yao-Jian2; Shen, Yue-Mao1,2
2009
发表期刊HELVETICA CHIMICA ACTA
ISSN0018-019X
卷号92期号:6页码:1184-1190
摘要Four new polyketides, namely rel-(2R,3S,4R,5R)-4-ethyltetrahydro-3-methyl-5-propylfuran-2,3-diol (1), methyl 5-[(1R)-1-hydroxyethyl]-gamma-oxofuran-2-butanoate (2), butyl 5-[(1R)-1-hydroxyethyl]-gamma-oxofuran-2-butanoate (3), and 3,4-dihydro-5'-[(1R)-1-hydroxyethyl][2,2'-bifuran]-5(2H)-one (4), together with three known ones, 5-[(1R)-1-hydroxethyl)-gamma-oxofuran-2-butanoic acid (5), phomopsolide B (6), and (2S,3S)-3,6-dihydro-6-oxo-2-[(1E)-2-{(4S,5S)-2,2,5-trimethyl-1,3-dioxolan-4-yl]ethenyl)-2H-pyran-3-yl (2E)-2-methylbut-2-enoate (7), were isolated from the submerged cultures of the endophytic fungal strain Diaporthe sp. XZ-07 of Camptotheca acuminate. The structures of the new compounds were established by 1D- and 2D-NMR and MS data and by Mosher's method. Compound 6 significantly inhibited the growth of human-tumor HeLa cells with an IC(50) of 5.7 mu g/ml by the MTT assay (MTT = 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide).
关键词Streptomyces-sp Oidiolactone-c Metabolites Oidiodendron Acid
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4850
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Xiamen Univ, Sch Life Sci, Xiamen 361005, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Yuan, Lin,Lin, Xiang,Zhao, Pei-Ji,et al. New Polyketides from Endophytic Diaporthe sp XZ-07[J]. HELVETICA CHIMICA ACTA,2009,92(6):1184-1190.
APA Yuan, Lin,Lin, Xiang,Zhao, Pei-Ji,Ma, Juan,Huang, Yao-Jian,&Shen, Yue-Mao.(2009).New Polyketides from Endophytic Diaporthe sp XZ-07.HELVETICA CHIMICA ACTA,92(6),1184-1190.
MLA Yuan, Lin,et al."New Polyketides from Endophytic Diaporthe sp XZ-07".HELVETICA CHIMICA ACTA 92.6(2009):1184-1190.
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