Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues
Chen, Gang1,2; Wang, Ye3,4; Gao, Suo1; He, Hong-Ping1; Li, Shun-Lin1; Zhang, Jian-Xin3,4; Ding, Jian5; Hao, Xiao-Jiang1,3,4
2009-03-01
Source PublicationJOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN0022-152X
Volume46Issue:2Pages:217-220
Abstract

A series of propargylic alcohol was synthesized by the addition of phenylacetylene to isatin and its N-substituted derivatives for the first time. This reaction involves activation of zinc reagent via coordination with carbonyl substrates that behave "ligand like." The bioactivities on protective effect on the apoplosis of PC12 cells induced by H2O2 and cytotoxicity against lung cancer A549 and P388 cell line of these compounds were investigated, and several compounds showed potent activities.

KeywordAnti-hiv Activity Spin Coupling-constants Kalata B1 Plant Cyclotides Oldenlandia-affinis Spatial Structure Circular Protein Cyclic Peptide Membrane Interaction Structural Motif
Subject AreaChemistry, Organic
DOI10.1002/jhet.58
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000265992700014
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4820
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Shaanxi, Peoples R China
3.Chinese Acad Sci, Guiyang 550002, Peoples R China
4.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China
5.Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
Recommended Citation
GB/T 7714
Chen, Gang,Wang, Ye,Gao, Suo,et al. Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY,2009,46(2):217-220.
APA Chen, Gang.,Wang, Ye.,Gao, Suo.,He, Hong-Ping.,Li, Shun-Lin.,...&Hao, Xiao-Jiang.(2009).Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues.JOURNAL OF HETEROCYCLIC CHEMISTRY,46(2),217-220.
MLA Chen, Gang,et al."Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues".JOURNAL OF HETEROCYCLIC CHEMISTRY 46.2(2009):217-220.
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