Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues
Chen, Gang1,2; Wang, Ye3,4; Gao, Suo1; He, Hong-Ping1; Li, Shun-Lin1; Zhang, Jian-Xin3,4; Ding, Jian5; Hao, Xiao-Jiang1,3,4
2009-03-01
发表期刊JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN0022-152X
卷号46期号:2页码:217-220
摘要

A series of propargylic alcohol was synthesized by the addition of phenylacetylene to isatin and its N-substituted derivatives for the first time. This reaction involves activation of zinc reagent via coordination with carbonyl substrates that behave "ligand like." The bioactivities on protective effect on the apoplosis of PC12 cells induced by H2O2 and cytotoxicity against lung cancer A549 and P388 cell line of these compounds were investigated, and several compounds showed potent activities.

关键词Anti-hiv Activity Spin Coupling-constants Kalata B1 Plant Cyclotides Oldenlandia-affinis Spatial Structure Circular Protein Cyclic Peptide Membrane Interaction Structural Motif
学科领域Chemistry, Organic
DOI10.1002/jhet.58
收录类别SCI ; IC
语种英语
WOS记录号WOS:000265992700014
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4820
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Shaanxi, Peoples R China
3.Chinese Acad Sci, Guiyang 550002, Peoples R China
4.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China
5.Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Chen, Gang,Wang, Ye,Gao, Suo,et al. Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY,2009,46(2):217-220.
APA Chen, Gang.,Wang, Ye.,Gao, Suo.,He, Hong-Ping.,Li, Shun-Lin.,...&Hao, Xiao-Jiang.(2009).Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues.JOURNAL OF HETEROCYCLIC CHEMISTRY,46(2),217-220.
MLA Chen, Gang,et al."Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues".JOURNAL OF HETEROCYCLIC CHEMISTRY 46.2(2009):217-220.
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