Approach to the Biosynthesis of Atisine-Type Diterpenoid Alkaloids
Zhao, Pei-Ji; Gao, Suo; Fan, Li-Ming; Nie, Jing-Lei; He, Hong-Ping; Zeng, Ying; Shen, Yue-Mao; Hao, Xiao-Jiang
2009-04-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume72Issue:4Pages:645-649
AbstractTo determine the biosynthesis pathway of the atisine-type diterpenoid alkaloids spiramines A/B and C/D, feeding experiments in in vitro Cultured plantlets; and enzymatic transformations in cell-free extracts were performed in combination with LCMS and tandem MS analyses. L-[2-(13)C,(15)N]Serine was used in the feeding experiments and enzymatic transformations, and the diterpene spiraminol was identified as it biosynthetic precursor of spiramine alkaloids. The LCMS and tandem MS spectra of the extracts from these experiments indicated that L-[2-(13)C,(15)N]serine was incorporated into spiramines A/B and C/D. The labeled reaction products show that L-serine is the one possible nitrogen source involved in the biosynthesis of atisine-type DAs.
KeywordRubescens Var.-taihangensis Rabdosia-pseudo-irrorata Kaurene Diterpenoids
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np800657j
Indexed BySCI ; IC
Language英语
WOS IDWOS:000265530000008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4816
Collection植物化学与西部植物资源持续利用国家重点实验室
AffiliationChinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Pei-Ji,Gao, Suo,Fan, Li-Ming,et al. Approach to the Biosynthesis of Atisine-Type Diterpenoid Alkaloids[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(4):645-649.
APA Zhao, Pei-Ji.,Gao, Suo.,Fan, Li-Ming.,Nie, Jing-Lei.,He, Hong-Ping.,...&Hao, Xiao-Jiang.(2009).Approach to the Biosynthesis of Atisine-Type Diterpenoid Alkaloids.JOURNAL OF NATURAL PRODUCTS,72(4),645-649.
MLA Zhao, Pei-Ji,et al."Approach to the Biosynthesis of Atisine-Type Diterpenoid Alkaloids".JOURNAL OF NATURAL PRODUCTS 72.4(2009):645-649.
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