Approach to the Biosynthesis of Atisine-Type Diterpenoid Alkaloids
Zhao, Pei-Ji; Gao, Suo; Fan, Li-Ming; Nie, Jing-Lei; He, Hong-Ping; Zeng, Ying; Shen, Yue-Mao; Hao, Xiao-Jiang
2009-04-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号72期号:4页码:645-649
摘要To determine the biosynthesis pathway of the atisine-type diterpenoid alkaloids spiramines A/B and C/D, feeding experiments in in vitro Cultured plantlets; and enzymatic transformations in cell-free extracts were performed in combination with LCMS and tandem MS analyses. L-[2-(13)C,(15)N]Serine was used in the feeding experiments and enzymatic transformations, and the diterpene spiraminol was identified as it biosynthetic precursor of spiramine alkaloids. The LCMS and tandem MS spectra of the extracts from these experiments indicated that L-[2-(13)C,(15)N]serine was incorporated into spiramines A/B and C/D. The labeled reaction products show that L-serine is the one possible nitrogen source involved in the biosynthesis of atisine-type DAs.
关键词Rubescens Var.-taihangensis Rabdosia-pseudo-irrorata Kaurene Diterpenoids
资助信息National Natural Science Foundation of China [30070087]
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np800657j
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000265530000008
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4816
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
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Zhao, Pei-Ji,Gao, Suo,Fan, Li-Ming,et al. Approach to the Biosynthesis of Atisine-Type Diterpenoid Alkaloids[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(4):645-649.
APA Zhao, Pei-Ji.,Gao, Suo.,Fan, Li-Ming.,Nie, Jing-Lei.,He, Hong-Ping.,...&Hao, Xiao-Jiang.(2009).Approach to the Biosynthesis of Atisine-Type Diterpenoid Alkaloids.JOURNAL OF NATURAL PRODUCTS,72(4),645-649.
MLA Zhao, Pei-Ji,et al."Approach to the Biosynthesis of Atisine-Type Diterpenoid Alkaloids".JOURNAL OF NATURAL PRODUCTS 72.4(2009):645-649.
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