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题名: Inhibition of NF-kappa B Activation and iNOS Induction by ent-Kaurane Diterpenoids in LPS-Stimulated RAW264.7 Murine Macrophages
作者: Aquila, Silvia2; Weng, Zhi-Ying3; Zeng, Yue-Qin3; null(孙汉董)1; Luis Rios, Jose2
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: TRIJUGIN-TYPE LIMONOIDS ; TRICHILIA-CONNAROIDES ; SANDORICUM-KOETJAPE ; CARBON SKELETON ; MELIACEAE ; BACCIFERA ; FRUTICOSA
英文摘要: Xerophilusin A (1), xerophilusin B (2), longikaurin B (3), and xerophilusin F (4) from Isodon xerophylus inhibit LPS-induced NO production in RAW 264.7 macrophages, with IC(50) values of 0.60, 0.23, 0.44, and 0.67 mu M, respectively. and they all inhibited mRNA production in these same cells. They decreased the luciferase activity in RAW 264.7 cells transiently transfected with the NF-kappa B-dependent luciferase reporter, with IC(50) values of 1.8, 0.7. 1.2, and 1.6 mu M, respectively. Compounds 1-3 reduced NF-kappa B activation, with compound 4 showing no effect, but p65 translocation from the cytoplasm to the nucleus and the LPS-induced degradation of 1 kappa B were inhibited by all four test Compounds. These findings indicate that ent-kauranes are potential anti-inflammatory agents, with a specific mechanism in which both the inhibition of NF-kappa B translocation and the consequent decrease of pro-inflammatory mediators are implicated.
出版日期: 2009-07-01
卷号: 72, 期号:7, 页码:1269-1272
DOI标识: 10.1021/np9001465
语种: 英语
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4790
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Univ Valencia, Fac Farm, Dept Farmacol, Valencia 46100, Spain
3.Kunming Med Coll, Dept Pharm, Kunming 650031, Peoples R China

Recommended Citation:
Aquila, S; Weng, ZY; Zeng, YQ; Sun, HD; Rios, JL.Inhibition of NF-kappa B Activation and iNOS Induction by ent-Kaurane Diterpenoids in LPS-Stimulated RAW264.7 Murine Macrophages,JOURNAL OF NATURAL PRODUCTS,2009,72(7):1269-1272
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