Inhibition of NF-kappa B Activation and iNOS Induction by ent-Kaurane Diterpenoids in LPS-Stimulated RAW264.7 Murine Macrophages
Aquila, Silvia2; Weng, Zhi-Ying3; Zeng, Yue-Qin3; Sun, Han-Dong1; Luis Rios, Jose2
2009-07-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号72期号:7页码:1269-1272
摘要Xerophilusin A (1), xerophilusin B (2), longikaurin B (3), and xerophilusin F (4) from Isodon xerophylus inhibit LPS-induced NO production in RAW 264.7 macrophages, with IC(50) values of 0.60, 0.23, 0.44, and 0.67 mu M, respectively. and they all inhibited mRNA production in these same cells. They decreased the luciferase activity in RAW 264.7 cells transiently transfected with the NF-kappa B-dependent luciferase reporter, with IC(50) values of 1.8, 0.7. 1.2, and 1.6 mu M, respectively. Compounds 1-3 reduced NF-kappa B activation, with compound 4 showing no effect, but p65 translocation from the cytoplasm to the nucleus and the LPS-induced degradation of 1 kappa B were inhibited by all four test Compounds. These findings indicate that ent-kauranes are potential anti-inflammatory agents, with a specific mechanism in which both the inhibition of NF-kappa B translocation and the consequent decrease of pro-inflammatory mediators are implicated.
关键词Trijugin-type Limonoids Trichilia-connaroides Sandoricum-koetjape Carbon Skeleton Meliaceae Baccifera Fruticosa
资助信息University of Valencia ; Spanish Government [SAF2006-06726, NS-FC30772637]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4790
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Univ Valencia, Fac Farm, Dept Farmacol, Valencia 46100, Spain
3.Kunming Med Coll, Dept Pharm, Kunming 650031, Peoples R China
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GB/T 7714
Aquila, Silvia,Weng, Zhi-Ying,Zeng, Yue-Qin,et al. Inhibition of NF-kappa B Activation and iNOS Induction by ent-Kaurane Diterpenoids in LPS-Stimulated RAW264.7 Murine Macrophages[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(7):1269-1272.
APA Aquila, Silvia,Weng, Zhi-Ying,Zeng, Yue-Qin,Sun, Han-Dong,&Luis Rios, Jose.(2009).Inhibition of NF-kappa B Activation and iNOS Induction by ent-Kaurane Diterpenoids in LPS-Stimulated RAW264.7 Murine Macrophages.JOURNAL OF NATURAL PRODUCTS,72(7),1269-1272.
MLA Aquila, Silvia,et al."Inhibition of NF-kappa B Activation and iNOS Induction by ent-Kaurane Diterpenoids in LPS-Stimulated RAW264.7 Murine Macrophages".JOURNAL OF NATURAL PRODUCTS 72.7(2009):1269-1272.
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