| Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells | |
| Xia, Chengfeng1,2,3; Zhang, Wenpeng1,2; Zhang, Yalong1,2; Woodward, Robert L.1,2; Wang, Jinhua1,2; Wang, Peng G.1,2 | |
| 2009-08-08 | |
| 发表期刊 | TETRAHEDRON
 |
| ISSN | 0040-4020 |
| 卷号 | 65期号:32页码:6390-6395 |
| 摘要 | When iNKT cells are stimulated by the CD1d presented exogenous alpha-galactosylceramide, a myriad of cytokines are released that trigger a variety of immune responses. However, the invisibility and poor aqueous Solubility of alpha-galactosylceramide during bioassays have rendered it difficult to study the aforementioned biological responses. Accordingly, a biotin-labelled alpha-galactosylceramide was prepared to facilitate detection of this antigen in the immune process. The problematic low solubility was also remedies via incorporation of a truncated acyl chain. (C) 2009 Elsevier Ltd. All rights reserved. |
| 关键词 | Natural Killer t Cells Alpha-galactosylceramide Biotin Cd1d |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1016/j.tet.2009.06.007 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000268736900015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/4770 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Ohio State Univ, Dept Chem, Columbus, OH 43210 USA 2.Ohio State Univ, Dept Biochem, Columbus, OH 43210 USA 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, Chengfeng,Zhang, Wenpeng,Zhang, Yalong,et al. Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells[J]. TETRAHEDRON,2009,65(32):6390-6395. |
| APA | Xia, Chengfeng,Zhang, Wenpeng,Zhang, Yalong,Woodward, Robert L.,Wang, Jinhua,&Wang, Peng G..(2009).Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells.TETRAHEDRON,65(32),6390-6395. |
| MLA | Xia, Chengfeng,et al."Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells".TETRAHEDRON 65.32(2009):6390-6395. |
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