Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells
Xia, Chengfeng1,2,3; Zhang, Wenpeng1,2; Zhang, Yalong1,2; Woodward, Robert L.1,2; Wang, Jinhua1,2; Wang, Peng G.1,2
2009-08-08
发表期刊TETRAHEDRON
ISSN0040-4020
卷号65期号:32页码:6390-6395
摘要When iNKT cells are stimulated by the CD1d presented exogenous alpha-galactosylceramide, a myriad of cytokines are released that trigger a variety of immune responses. However, the invisibility and poor aqueous Solubility of alpha-galactosylceramide during bioassays have rendered it difficult to study the aforementioned biological responses. Accordingly, a biotin-labelled alpha-galactosylceramide was prepared to facilitate detection of this antigen in the immune process. The problematic low solubility was also remedies via incorporation of a truncated acyl chain. (C) 2009 Elsevier Ltd. All rights reserved.
关键词Natural Killer t Cells Alpha-galactosylceramide Biotin Cd1d
资助信息Ohio State University
学科领域Chemistry, Organic
DOI10.1016/j.tet.2009.06.007
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000268736900015
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4770
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Ohio State Univ, Dept Chem, Columbus, OH 43210 USA
2.Ohio State Univ, Dept Biochem, Columbus, OH 43210 USA
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
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Xia, Chengfeng,Zhang, Wenpeng,Zhang, Yalong,et al. Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells[J]. TETRAHEDRON,2009,65(32):6390-6395.
APA Xia, Chengfeng,Zhang, Wenpeng,Zhang, Yalong,Woodward, Robert L.,Wang, Jinhua,&Wang, Peng G..(2009).Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells.TETRAHEDRON,65(32),6390-6395.
MLA Xia, Chengfeng,et al."Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells".TETRAHEDRON 65.32(2009):6390-6395.
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