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题名: Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells
作者: null(夏成峰)1, 2, 3; Zhang, Wenpeng1, 2; Zhang, Yalong1, 2; Woodward, Robert L.1, 2; Wang, Jinhua1, 2; Wang, Peng G.1, 2
刊名: TETRAHEDRON
关键词: Natural killer T cells ; alpha-Galactosylceramide ; Biotin ; CD1d
英文摘要: When iNKT cells are stimulated by the CD1d presented exogenous alpha-galactosylceramide, a myriad of cytokines are released that trigger a variety of immune responses. However, the invisibility and poor aqueous Solubility of alpha-galactosylceramide during bioassays have rendered it difficult to study the aforementioned biological responses. Accordingly, a biotin-labelled alpha-galactosylceramide was prepared to facilitate detection of this antigen in the immune process. The problematic low solubility was also remedies via incorporation of a truncated acyl chain. (C) 2009 Elsevier Ltd. All rights reserved.
出版日期: 2009-08-08
卷号: 65, 期号:32, 页码:6390-6395
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry, Organic
ISSN号: 0040-4020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4770
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Ohio State Univ, Dept Chem, Columbus, OH 43210 USA
2.Ohio State Univ, Dept Biochem, Columbus, OH 43210 USA
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

Recommended Citation:
Xia, CF; Zhang, WP; Zhang, YL; Woodward, RL; Wang, JH; Wang, PG.Facile synthesis of biotin-labelled alpha-galactosylceramide as antigen for invariant natural killer T cells,TETRAHEDRON,2009,65(32):6390-6395
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