Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase
Jo, Michiko; Nakamura, Norio; Kakiuchi, Nobuko; Komatsu, Katsuko; Qui, Ming-hua; Shimotohno, Kumiko; Shimotohno, Kunitada; Hattori, Masao
Corresponding AuthorHattori, M, Toyama Univ, Inst Nat Med, 2630 Sugitani, Toyama 9300194, Japan
AbstractFor the purpose of developing novel antihepatitis C virus (HCV) agents from natural resources, 93 Yunnan crude drugs were screened for their inhibitory effects on RNA-dependent RNA polymerase (RdRp) of HCV. Although 71 methanol extracts and 50 water extracts inhibited HCV-RdRp by more than 50% at a concentration of 50 mu g/ml, the majority of them contained a high percentage of tannins. However, methanol extracts of Plumbago zeylanica (branch), Maytenus fookerii (leaf) and Huashidancha (Y61, branch and leaf), and water extracts of Potentilla griffithii (whole plant) and Salva yunnanensis (underground part), having IC50 values of less than 10 mu g/ml, showed less than 10% tannin content. In addition, from a methanol extract of Tripterygium hypoglaucum (root bark), demethylzeylasteral was isolated as a strongly inhibitory Substance against HCV-RdRp.
KeywordTripterygium Hypoglaucum Demethylzeylasteral Hepatitis c Virus Rna-dependent Rna Polymerase Yunnan Crude Drugs
Subject AreaChemistry, Medicinal ; Pharmacology & Pharmacy
Indexed BySCI
WOS IDWOS:000202947900007
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Document Type期刊论文
Affiliation1.Toyama Univ, Inst Nat Med, Toyama 9300194, Japan
2.Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9201192, Japan
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
4.Kyoritsu Univ Pharm, Minato Ku, Tokyo 1058512, Japan
5.Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Sakyo Ku, Kyoto 6068507, Japan
Recommended Citation
GB/T 7714
Jo, Michiko,Nakamura, Norio,Kakiuchi, Nobuko,et al. Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase[J]. JOURNAL OF NATURAL MEDICINES,2006,60(3):217-224.
APA Jo, Michiko.,Nakamura, Norio.,Kakiuchi, Nobuko.,Komatsu, Katsuko.,Qui, Ming-hua.,...&Hattori, Masao.(2006).Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase.JOURNAL OF NATURAL MEDICINES,60(3),217-224.
MLA Jo, Michiko,et al."Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase".JOURNAL OF NATURAL MEDICINES 60.3(2006):217-224.
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