| Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase | |
| Jo, Michiko; Nakamura, Norio; Kakiuchi, Nobuko; Komatsu, Katsuko; Qui, Ming-hua; Shimotohno, Kumiko; Shimotohno, Kunitada; Hattori, Masao | |
| 通讯作者 | Hattori, M, Toyama Univ, Inst Nat Med, 2630 Sugitani, Toyama 9300194, Japan |
| 2006 | |
| 发表期刊 | JOURNAL OF NATURAL MEDICINES
 |
| ISSN | 1340-3443 |
| 卷号 | 60期号:3页码:217-224 |
| 摘要 | For the purpose of developing novel antihepatitis C virus (HCV) agents from natural resources, 93 Yunnan crude drugs were screened for their inhibitory effects on RNA-dependent RNA polymerase (RdRp) of HCV. Although 71 methanol extracts and 50 water extracts inhibited HCV-RdRp by more than 50% at a concentration of 50 mu g/ml, the majority of them contained a high percentage of tannins. However, methanol extracts of Plumbago zeylanica (branch), Maytenus fookerii (leaf) and Huashidancha (Y61, branch and leaf), and water extracts of Potentilla griffithii (whole plant) and Salva yunnanensis (underground part), having IC50 values of less than 10 mu g/ml, showed less than 10% tannin content. In addition, from a methanol extract of Tripterygium hypoglaucum (root bark), demethylzeylasteral was isolated as a strongly inhibitory Substance against HCV-RdRp. |
| 关键词 | Tripterygium Hypoglaucum Demethylzeylasteral Hepatitis c Virus Rna-dependent Rna Polymerase Yunnan Crude Drugs |
| 学科领域 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1007/s11418-006-0041-7 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000202947900007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/4760 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Toyama Univ, Inst Nat Med, Toyama 9300194, Japan 2.Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9201192, Japan 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 4.Kyoritsu Univ Pharm, Minato Ku, Tokyo 1058512, Japan 5.Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Sakyo Ku, Kyoto 6068507, Japan |
| 推荐引用方式 GB/T 7714 | Jo, Michiko,Nakamura, Norio,Kakiuchi, Nobuko,et al. Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase[J]. JOURNAL OF NATURAL MEDICINES,2006,60(3):217-224. |
| APA | Jo, Michiko.,Nakamura, Norio.,Kakiuchi, Nobuko.,Komatsu, Katsuko.,Qui, Ming-hua.,...&Hattori, Masao.(2006).Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase.JOURNAL OF NATURAL MEDICINES,60(3),217-224. |
| MLA | Jo, Michiko,et al."Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase".JOURNAL OF NATURAL MEDICINES 60.3(2006):217-224. |
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