Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase
Jo, Michiko; Nakamura, Norio; Kakiuchi, Nobuko; Komatsu, Katsuko; Qui, Ming-hua; Shimotohno, Kumiko; Shimotohno, Kunitada; Hattori, Masao
2006
发表期刊JOURNAL OF NATURAL MEDICINES
ISSN1340-3443
卷号60期号:3页码:217-224
摘要For the purpose of developing novel antihepatitis C virus (HCV) agents from natural resources, 93 Yunnan crude drugs were screened for their inhibitory effects on RNA-dependent RNA polymerase (RdRp) of HCV. Although 71 methanol extracts and 50 water extracts inhibited HCV-RdRp by more than 50% at a concentration of 50 mu g/ml, the majority of them contained a high percentage of tannins. However, methanol extracts of Plumbago zeylanica (branch), Maytenus fookerii (leaf) and Huashidancha (Y61, branch and leaf), and water extracts of Potentilla griffithii (whole plant) and Salva yunnanensis (underground part), having IC50 values of less than 10 mu g/ml, showed less than 10% tannin content. In addition, from a methanol extract of Tripterygium hypoglaucum (root bark), demethylzeylasteral was isolated as a strongly inhibitory Substance against HCV-RdRp.
关键词Tripterygium Hypoglaucum Demethylzeylasteral Hepatitis c Virus Rna-dependent Rna Polymerase Yunnan Crude Drugs
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1007/s11418-006-0041-7
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000202947900007
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4760
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Toyama Univ, Inst Nat Med, Toyama 9300194, Japan
2.Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9201192, Japan
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
4.Kyoritsu Univ Pharm, Minato Ku, Tokyo 1058512, Japan
5.Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Sakyo Ku, Kyoto 6068507, Japan
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Jo, Michiko,Nakamura, Norio,Kakiuchi, Nobuko,et al. Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase[J]. JOURNAL OF NATURAL MEDICINES,2006,60(3):217-224.
APA Jo, Michiko.,Nakamura, Norio.,Kakiuchi, Nobuko.,Komatsu, Katsuko.,Qui, Ming-hua.,...&Hattori, Masao.(2006).Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase.JOURNAL OF NATURAL MEDICINES,60(3),217-224.
MLA Jo, Michiko,et al."Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase".JOURNAL OF NATURAL MEDICINES 60.3(2006):217-224.
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