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题名: Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase
作者: Jo, Michiko; Nakamura, Norio; Kakiuchi, Nobuko; Komatsu, Katsuko; Qui, Ming-hua; Shimotohno, Kumiko; Shimotohno, Kunitada; Hattori, Masao
刊名: JOURNAL OF NATURAL MEDICINES
关键词: Tripterygium hypoglaucum ; demethylzeylasteral ; Hepatitis C virus ; RNA-dependent RNA polymerase ; Yunnan crude drugs
英文摘要: For the purpose of developing novel antihepatitis C virus (HCV) agents from natural resources, 93 Yunnan crude drugs were screened for their inhibitory effects on RNA-dependent RNA polymerase (RdRp) of HCV. Although 71 methanol extracts and 50 water extracts inhibited HCV-RdRp by more than 50% at a concentration of 50 mu g/ml, the majority of them contained a high percentage of tannins. However, methanol extracts of Plumbago zeylanica (branch), Maytenus fookerii (leaf) and Huashidancha (Y61, branch and leaf), and water extracts of Potentilla griffithii (whole plant) and Salva yunnanensis (underground part), having IC50 values of less than 10 mu g/ml, showed less than 10% tannin content. In addition, from a methanol extract of Tripterygium hypoglaucum (root bark), demethylzeylasteral was isolated as a strongly inhibitory Substance against HCV-RdRp.
出版日期: 2006
卷号: 60, 期号:3, 页码:217-224
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 1340-3443
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4760
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Toyama Univ, Inst Nat Med, Toyama 9300194, Japan
2.Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9201192, Japan
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
4.Kyoritsu Univ Pharm, Minato Ku, Tokyo 1058512, Japan
5.Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Sakyo Ku, Kyoto 6068507, Japan

Recommended Citation:
Jo, M; Nakamura, N; Kakiuchi, N; Komatsu, K; Qui, MH; Shimotohno, K; Shimotohno, K; Hattori, M.Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase,JOURNAL OF NATURAL MEDICINES,2006,60(3):217-224
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