Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra arillaris

	Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra arillaris
	Qiu, MH; Nakamura, N ; Min, BS ; Hattori, M
通讯作者	Qiu, MH, Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China
	2005
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	2 期号:7 页码:866-871
摘要	Two new, bioactive, pregnane-based natural products, pachysanonin (=3 beta,11 alpha,12 beta)-12-acetoxy-3-(dimethylamino)-11-[(3,4-dimethylpent-3-enoyl)oxy]pregnan-20-one; 1) and pachysanone (=(11 alpha,12 beta)-12-acetoxy-11-[(3,4-dimethylpent-3-enoyl)oxy]pregnan-3,20-dion; 2) have been isolated from Pachysandra axillaris. Their structures were determined by spectroscopic methods, and, in the case of 2, by single-crystal X-ray crystallography (Figure). Compound 2 showed significant antitumor activity against Lewis lung carcinoma (LCC) tumor cells, with an IC50 value of 0.020 +/- 0.006 mu g/ml, which is equal or even lower than those of the well-known natural antitumor agents harringtonine (0.02), homoharringtonine (0.15), and adriamycin (0.06 mu g/ml; positive control).
关键词	Relative Configuration L-755 Alzheimers-disease 807 Militarinone-a Metabolites Targets
学科领域	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
收录类别	SCI
语种	英语
WOS记录号	WOS:000231048200003
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4756
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China 2.Toyama Med & Pharmaceut Univ, Res Inst Tradit Sino Japanese Med, Toyama 9300194, Japan
推荐引用方式 GB/T 7714	Qiu, MH,Nakamura, N,Min, BS,et al. Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra arillaris[J]. CHEMISTRY & BIODIVERSITY,2005,2(7):866-871.
APA	Qiu, MH,Nakamura, N,Min, BS,&Hattori, M.(2005).Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra arillaris.CHEMISTRY & BIODIVERSITY,2(7),866-871.
MLA	Qiu, MH,et al."Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra arillaris".CHEMISTRY & BIODIVERSITY 2.7(2005):866-871.

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