Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra arillaris
Qiu, MH; Nakamura, N; Min, BS; Hattori, M
2005
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号2期号:7页码:866-871
摘要Two new, bioactive, pregnane-based natural products, pachysanonin (=3 beta,11 alpha,12 beta)-12-acetoxy-3-(dimethylamino)-11-[(3,4-dimethylpent-3-enoyl)oxy]pregnan-20-one; 1) and pachysanone (=(11 alpha,12 beta)-12-acetoxy-11-[(3,4-dimethylpent-3-enoyl)oxy]pregnan-3,20-dion; 2) have been isolated from Pachysandra axillaris. Their structures were determined by spectroscopic methods, and, in the case of 2, by single-crystal X-ray crystallography (Figure). Compound 2 showed significant antitumor activity against Lewis lung carcinoma (LCC) tumor cells, with an IC50 value of 0.020 +/- 0.006 mu g/ml, which is equal or even lower than those of the well-known natural antitumor agents harringtonine (0.02), homoharringtonine (0.15), and adriamycin (0.06 mu g/ml; positive control).
关键词Relative Configuration L-755 Alzheimers-disease 807 Militarinone-a Metabolites Targets
学科领域Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000231048200003
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4756
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China
2.Toyama Med & Pharmaceut Univ, Res Inst Tradit Sino Japanese Med, Toyama 9300194, Japan
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Qiu, MH,Nakamura, N,Min, BS,et al. Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra arillaris[J]. CHEMISTRY & BIODIVERSITY,2005,2(7):866-871.
APA Qiu, MH,Nakamura, N,Min, BS,&Hattori, M.(2005).Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra arillaris.CHEMISTRY & BIODIVERSITY,2(7),866-871.
MLA Qiu, MH,et al."Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra arillaris".CHEMISTRY & BIODIVERSITY 2.7(2005):866-871.
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