| Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica | |
Xie, Bai-Bo1,2; Liu, Hai-Yang1 ; Ni, Wei1; Chen, Chang-Xiang1
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| 2009-11-04 | |
| 发表期刊 | STEROIDS
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| ISSN | 0039-128X |
| 卷号 | 74期号:12页码:950-955 |
| 摘要 | A further phytochemical investigation on the whole plants of Ypsilandra thibetica yielded one sapogenin and 12 spirostanol saponins. Five of these are new compounds, designated as ypsilandrosides C-G (2-6). Their structures were determined by detailed spectroscopic analysis, including extensive 1D and 2D NMR data, and by the result of a hydrolytic reaction. Compounds 2-5 were rare steroidal saponins that an apiofuranosyl unit was directly linked at C-3 of the aglycone. Selected spirostanol saponins (2-6, 9) were tested for their cytotoxic activities against K562, SPC-A-1, BGC-823, Eca-109, and AGS cell lines. Compounds 6 and 9 showed moderate inhibitory activity against all five cell lines. The antifungal properties of the new spirostanol saponins (2-6) against Candida albicans were also determined. (C) 2009 Elsevier Inc. All rights reserved. |
| 关键词 | Ypsilandra Thibetica Liliaceae Spirostanol Saponins Ypsilandrosides C-g Cytotoxicity Antifungal Activity |
| 学科领域 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| DOI | 10.1016/j.steroids.2009.07.001 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000270759500012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/4668 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Bai-Bo,Liu, Hai-Yang,Ni, Wei,et al. Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica[J]. STEROIDS,2009,74(12):950-955. |
| APA | Xie, Bai-Bo,Liu, Hai-Yang,Ni, Wei,&Chen, Chang-Xiang.(2009).Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica.STEROIDS,74(12),950-955. |
| MLA | Xie, Bai-Bo,et al."Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica".STEROIDS 74.12(2009):950-955. |
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