Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica
Xie, Bai-Bo1,2; Liu, Hai-Yang1; Ni, Wei1; Chen, Chang-Xiang1
2009-11-04
Source PublicationSTEROIDS
ISSN0039-128X
Volume74Issue:12Pages:950-955
AbstractA further phytochemical investigation on the whole plants of Ypsilandra thibetica yielded one sapogenin and 12 spirostanol saponins. Five of these are new compounds, designated as ypsilandrosides C-G (2-6). Their structures were determined by detailed spectroscopic analysis, including extensive 1D and 2D NMR data, and by the result of a hydrolytic reaction. Compounds 2-5 were rare steroidal saponins that an apiofuranosyl unit was directly linked at C-3 of the aglycone. Selected spirostanol saponins (2-6, 9) were tested for their cytotoxic activities against K562, SPC-A-1, BGC-823, Eca-109, and AGS cell lines. Compounds 6 and 9 showed moderate inhibitory activity against all five cell lines. The antifungal properties of the new spirostanol saponins (2-6) against Candida albicans were also determined. (C) 2009 Elsevier Inc. All rights reserved.
KeywordYpsilandra Thibetica Liliaceae Spirostanol Saponins Ypsilandrosides C-g Cytotoxicity Antifungal Activity
Subject AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
DOI10.1016/j.steroids.2009.07.001
Indexed BySCI ; IC
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000270759500012
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4668
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Xie, Bai-Bo,Liu, Hai-Yang,Ni, Wei,et al. Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica[J]. STEROIDS,2009,74(12):950-955.
APA Xie, Bai-Bo,Liu, Hai-Yang,Ni, Wei,&Chen, Chang-Xiang.(2009).Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica.STEROIDS,74(12),950-955.
MLA Xie, Bai-Bo,et al."Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica".STEROIDS 74.12(2009):950-955.
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