Pregnane alkaloids from Pachysandra axillaris

doi:10.1016/j.steroids.2010.05.005

	Pregnane alkaloids from Pachysandra axillaris
	Sun, Yun 1,2,3; Yan, Yu-Xin 1,2; Chen, Jian-Chao 1; Lu, Lu 1,2; Zhang, Xian-Min 1; Li, Yan1 ; Qiu, Ming-Hua1
	2010-12-01
发表期刊	STEROIDS
ISSN	0039-128X
卷号	75 期号:12 页码:818-824
摘要	Nine new pregnane alkaloids, pachysamines J-R (1-9), together with seven known ones, were isolated from Pachysandra axillaris. The chemical structures of the new alkaloids were elucidated by spectroscopic methods. All the compounds were evaluated for their inhibitory activities against HL-60, SMMC-7721, A549, SK-BR-3, and PANC-1 cell lines. Compound 15 possessed moderate activities against A-549, SK-BR-3, and PANC-1 cells, with the IC(50) values of 11.17, 4.17, and 10.76 mu M, respectively. Besides, compound 11 showed cytotoxicities against A-549 cell, with the IC(50) values as 24.94 mu M. (C) 2010 Published by Elsevier Inc.
关键词	Pregnane Alkaloids Pachysandra Axillaris Cytotoxic Activity
学科领域	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
DOI	10.1016/j.steroids.2010.05.005
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000281932500004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4664
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Yunnan Univ Tradit Chinese Med, Kunming 650000, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Sun, Yun,Yan, Yu-Xin,Chen, Jian-Chao,et al. Pregnane alkaloids from Pachysandra axillaris[J]. STEROIDS,2010,75(12):818-824.
APA	Sun, Yun.,Yan, Yu-Xin.,Chen, Jian-Chao.,Lu, Lu.,Zhang, Xian-Min.,...&Qiu, Ming-Hua.(2010).Pregnane alkaloids from Pachysandra axillaris.STEROIDS,75(12),818-824.
MLA	Sun, Yun,et al."Pregnane alkaloids from Pachysandra axillaris".STEROIDS 75.12(2010):818-824.

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