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题名: Pregnane alkaloids from Pachysandra axillaris
作者: Sun, Yun1, 2, 3; Yan, Yu-Xin1, 2; Chen, Jian-Chao1; Lu, Lu1, 2; Zhang, Xian-Min1; null(李艳)1; null(邱明华)1
刊名: STEROIDS
关键词: Pregnane alkaloids ; Pachysandra axillaris ; Cytotoxic activity
英文摘要: Nine new pregnane alkaloids, pachysamines J-R (1-9), together with seven known ones, were isolated from Pachysandra axillaris. The chemical structures of the new alkaloids were elucidated by spectroscopic methods. All the compounds were evaluated for their inhibitory activities against HL-60, SMMC-7721, A549, SK-BR-3, and PANC-1 cell lines. Compound 15 possessed moderate activities against A-549, SK-BR-3, and PANC-1 cells, with the IC(50) values of 11.17, 4.17, and 10.76 mu M, respectively. Besides, compound 11 showed cytotoxicities against A-549 cell, with the IC(50) values as 24.94 mu M. (C) 2010 Published by Elsevier Inc.
出版日期: 2010-12-01
卷号: 75, 期号:12, 页码:818-824
DOI标识: 10.1016/j.steroids.2010.05.005
语种: 英语
收录类别: SCI ; IC
学科分类: Biochemistry & Molecular Biology; Endocrinology & Metabolism
ISSN号: 0039-128X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4664
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Yunnan Univ Tradit Chinese Med, Kunming 650000, Yunnan, Peoples R China

Recommended Citation:
Sun, Y; Yan, YX; Chen, JC; Lu, L; Zhang, XM; Li, Y; Qiu, MH.Pregnane alkaloids from Pachysandra axillaris,STEROIDS,2010,75(12):818-824
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