Pregnane alkaloids from Pachysandra axillaris
Sun, Yun1,2,3; Yan, Yu-Xin1,2; Chen, Jian-Chao1; Lu, Lu1,2; Zhang, Xian-Min1; Li, Yan1; Qiu, Ming-Hua1
2010-12-01
发表期刊STEROIDS
ISSN0039-128X
卷号75期号:12页码:818-824
摘要Nine new pregnane alkaloids, pachysamines J-R (1-9), together with seven known ones, were isolated from Pachysandra axillaris. The chemical structures of the new alkaloids were elucidated by spectroscopic methods. All the compounds were evaluated for their inhibitory activities against HL-60, SMMC-7721, A549, SK-BR-3, and PANC-1 cell lines. Compound 15 possessed moderate activities against A-549, SK-BR-3, and PANC-1 cells, with the IC(50) values of 11.17, 4.17, and 10.76 mu M, respectively. Besides, compound 11 showed cytotoxicities against A-549 cell, with the IC(50) values as 24.94 mu M. (C) 2010 Published by Elsevier Inc.
关键词Pregnane Alkaloids Pachysandra Axillaris Cytotoxic Activity
资助信息Foundation of Key State Lab. of Phytochemistry and Plant Resources in West China [P2008ZZ05]; CAS ; Chinese Academy of Sciences (CAS) [KSCX2-YW-G-038, KSCX2-YW-R-194, 29KZCX2-XB2-15-03]; National Natural Science Foundation of China [30772636]
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4664
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Yunnan Univ Tradit Chinese Med, Kunming 650000, Yunnan, Peoples R China
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Sun, Yun,Yan, Yu-Xin,Chen, Jian-Chao,et al. Pregnane alkaloids from Pachysandra axillaris[J]. STEROIDS,2010,75(12):818-824.
APA Sun, Yun.,Yan, Yu-Xin.,Chen, Jian-Chao.,Lu, Lu.,Zhang, Xian-Min.,...&Qiu, Ming-Hua.(2010).Pregnane alkaloids from Pachysandra axillaris.STEROIDS,75(12),818-824.
MLA Sun, Yun,et al."Pregnane alkaloids from Pachysandra axillaris".STEROIDS 75.12(2010):818-824.
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