Cytotoxic ent-kauranoids from Isodon leucophyllus
Zhao, AH; Xiang, W; Na, Z; Wang, ZY; Lin, ZW; Sun, HD
AbstractTwo new compounds, baiyecrystals D and E ( 1 , 2 ), together with eight known analogues, xerophilusin B ( 4 ), macrocalin B ( 5 ), oridonin ( 6 ), rosthorin A ( 7 ), lasiocarpanin ( 8 ), rabdoternin A ( 9 ) and phyllostachysin A ( 10 ) and B ( 11 ), were isolated from the aerial parts of Isodon leucophyllus . The structures of 1 and 2 and 4 - 11 were elucidated on the basis of spectroscopic methods, especially the 2D NMR spectral analysis. Compounds 2 , 6 - 8 and 10 were evaluated for their antineoplastic activities in vitro . Among them, lasiocarpanin ( 8 ) showed significant inhibitory activities against K562 and Bcap37 cells, with the IC50 values of 0.13 and 1.26 mug mL(-1) , respectively, which were lower than those of the positive control.
KeywordIsodon Leucophyllus Labiatae Ent-kaurane Diterpenoids Baiyecrystal d Baiyecrystal e Cytotoxic Activities
Subject AreaPlant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
Indexed BySCI ; IC
WOS Research AreaPlant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000186924600009
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Kunming Med Coll, Dept Pharmacol, Kunming 650031, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhao, AH,Xiang, W,Na, Z,et al. Cytotoxic ent-kauranoids from Isodon leucophyllus[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2004,6(2):145-150.
APA Zhao, AH,Xiang, W,Na, Z,Wang, ZY,Lin, ZW,&Sun, HD.(2004).Cytotoxic ent-kauranoids from Isodon leucophyllus.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,6(2),145-150.
MLA Zhao, AH,et al."Cytotoxic ent-kauranoids from Isodon leucophyllus".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 6.2(2004):145-150.
Files in This Item: Download All
File Name/Size DocType Version Access License
201202240029.pdf(122KB) 开放获取--View Download
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhao, AH]'s Articles
[Xiang, W]'s Articles
[Na, Z]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhao, AH]'s Articles
[Xiang, W]'s Articles
[Na, Z]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhao, AH]'s Articles
[Xiang, W]'s Articles
[Na, Z]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 201202240029.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.