Cytotoxic ent-kauranoids from Isodon leucophyllus
Zhao, AH; Xiang, W; Na, Z; Wang, ZY; Lin, ZW; Sun, HD
2004-06-01
Source PublicationJOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN1028-6020
Volume6Issue:2Pages:145-150
AbstractTwo new compounds, baiyecrystals D and E ( 1 , 2 ), together with eight known analogues, xerophilusin B ( 4 ), macrocalin B ( 5 ), oridonin ( 6 ), rosthorin A ( 7 ), lasiocarpanin ( 8 ), rabdoternin A ( 9 ) and phyllostachysin A ( 10 ) and B ( 11 ), were isolated from the aerial parts of Isodon leucophyllus . The structures of 1 and 2 and 4 - 11 were elucidated on the basis of spectroscopic methods, especially the 2D NMR spectral analysis. Compounds 2 , 6 - 8 and 10 were evaluated for their antineoplastic activities in vitro . Among them, lasiocarpanin ( 8 ) showed significant inhibitory activities against K562 and Bcap37 cells, with the IC50 values of 0.13 and 1.26 mug mL(-1) , respectively, which were lower than those of the positive control.
KeywordIsodon Leucophyllus Labiatae Ent-kaurane Diterpenoids Baiyecrystal d Baiyecrystal e Cytotoxic Activities
Subject AreaPlant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1080/1028602031000147410
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000186924600009
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4656
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Kunming Med Coll, Dept Pharmacol, Kunming 650031, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhao, AH,Xiang, W,Na, Z,et al. Cytotoxic ent-kauranoids from Isodon leucophyllus[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2004,6(2):145-150.
APA Zhao, AH,Xiang, W,Na, Z,Wang, ZY,Lin, ZW,&Sun, HD.(2004).Cytotoxic ent-kauranoids from Isodon leucophyllus.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,6(2),145-150.
MLA Zhao, AH,et al."Cytotoxic ent-kauranoids from Isodon leucophyllus".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 6.2(2004):145-150.
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