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题名: Cytotoxic ent-kauranoids from Isodon leucophyllus
作者: Zhao, AH; Xiang, W; Na, Z; Wang, ZY; Lin, ZW; null(孙汉董)
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
关键词: Isodon leucophyllus ; Labiatae ; ent-kaurane diterpenoids ; baiyecrystal D ; baiyecrystal E ; cytotoxic activities
英文摘要: Two new compounds, baiyecrystals D and E ( 1 , 2 ), together with eight known analogues, xerophilusin B ( 4 ), macrocalin B ( 5 ), oridonin ( 6 ), rosthorin A ( 7 ), lasiocarpanin ( 8 ), rabdoternin A ( 9 ) and phyllostachysin A ( 10 ) and B ( 11 ), were isolated from the aerial parts of Isodon leucophyllus . The structures of 1 and 2 and 4 - 11 were elucidated on the basis of spectroscopic methods, especially the 2D NMR spectral analysis. Compounds 2 , 6 - 8 and 10 were evaluated for their antineoplastic activities in vitro . Among them, lasiocarpanin ( 8 ) showed significant inhibitory activities against K562 and Bcap37 cells, with the IC50 values of 0.13 and 1.26 mug mL(-1) , respectively, which were lower than those of the positive control.
出版日期: 2004-06-01
卷号: 6, 期号:2, 页码:145-150
DOI标识: 10.1080/1028602031000147410
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Applied; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 1028-6020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4656
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Kunming Med Coll, Dept Pharmacol, Kunming 650031, Yunnan, Peoples R China

Recommended Citation:
Zhao, AH; Xiang, W; Na, Z; Wang, ZY; Lin, ZW; Sun, HD.Cytotoxic ent-kauranoids from Isodon leucophyllus,JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2004,6(2):145-150
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