Cytotoxic ent-kauranoids from Isodon leucophyllus

doi:10.1080/1028602031000147410

	Cytotoxic ent-kauranoids from Isodon leucophyllus
	Zhao, AH ; Xiang, W ; Na, Z ; Wang, ZY ; Lin, ZW ; Sun, HD
	2004-06-01
发表期刊	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN	1028-6020
卷号	6 期号:2 页码:145-150
摘要	Two new compounds, baiyecrystals D and E ( 1 , 2 ), together with eight known analogues, xerophilusin B ( 4 ), macrocalin B ( 5 ), oridonin ( 6 ), rosthorin A ( 7 ), lasiocarpanin ( 8 ), rabdoternin A ( 9 ) and phyllostachysin A ( 10 ) and B ( 11 ), were isolated from the aerial parts of Isodon leucophyllus . The structures of 1 and 2 and 4 - 11 were elucidated on the basis of spectroscopic methods, especially the 2D NMR spectral analysis. Compounds 2 , 6 - 8 and 10 were evaluated for their antineoplastic activities in vitro . Among them, lasiocarpanin ( 8 ) showed significant inhibitory activities against K562 and Bcap37 cells, with the IC50 values of 0.13 and 1.26 mug mL(-1) , respectively, which were lower than those of the positive control.
关键词	Isodon Leucophyllus Labiatae Ent-kaurane Diterpenoids Baiyecrystal d Baiyecrystal e Cytotoxic Activities
学科领域	Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1080/1028602031000147410
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000186924600009
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4656
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Kunming Med Coll, Dept Pharmacol, Kunming 650031, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhao, AH,Xiang, W,Na, Z,et al. Cytotoxic ent-kauranoids from Isodon leucophyllus[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2004,6(2):145-150.
APA	Zhao, AH,Xiang, W,Na, Z,Wang, ZY,Lin, ZW,&Sun, HD.(2004).Cytotoxic ent-kauranoids from Isodon leucophyllus.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,6(2),145-150.
MLA	Zhao, AH,et al."Cytotoxic ent-kauranoids from Isodon leucophyllus".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 6.2(2004):145-150.

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