New isoprenylated flavones, artochamins A-E, and cytotoxic principles from Artocarpus chama
Wang, YH; Hou, AJ; Chen, L; Chen, DF; Sun, HD; Zhao, QS; Bastow, KF; Nakanish, Y; Wang, XH; Lee, KH
Corresponding AuthorHou, AJ, Fudan Univ, Sch Pharm, Dept Pharmacognosy, 138 Yi Xue Yuan Rd, Shanghai 200032, Peoples R China
2004-05-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume67Issue:5Pages:757-761
AbstractFive new isoprenylated flavones, artochamins A-E (1-5), together with eight known flavones (6-13), were isolated from the roots of Artocarpus chama. All structures were elucidated by spectroscopic methods. Artonin E (12) showed strong cytotoxicity against 1A9 (ovarian), significant activity against MCF-7 (breast adenocarcinoma), and moderate activity against HCT-8 (ileocecal) and MDA-MB-231 (breast adenocarcinoma) tumor cell lines. Artochamin C (3) was more potent against MCF-7, 1A9, HCT-8, and SK-MEL-2 (melanoma) than A549 (lung carcinoma), KB (epidermoid carcinoma of the nasopharynx), and its drug-resistant (KB-VIN) variant. Artocarpin (6) displayed weak but relatively broad inhibitory effects compared with 3 and 12.
KeywordParis-polyphylla Sm Domestic Plants Var Pluriflorum Components Glycosides Rhizomes Constituents Spirostanol Sapogenins Leaves
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np030467y
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000221804700003
Citation statistics
Cited Times:62[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4634
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200032, Peoples R China
2.Acad Sinica, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China
3.Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Nat Prod Lab, Chapel Hill, NC 27599 USA
Recommended Citation
GB/T 7714
Wang, YH,Hou, AJ,Chen, L,et al. New isoprenylated flavones, artochamins A-E, and cytotoxic principles from Artocarpus chama[J]. JOURNAL OF NATURAL PRODUCTS,2004,67(5):757-761.
APA Wang, YH.,Hou, AJ.,Chen, L.,Chen, DF.,Sun, HD.,...&Lee, KH.(2004).New isoprenylated flavones, artochamins A-E, and cytotoxic principles from Artocarpus chama.JOURNAL OF NATURAL PRODUCTS,67(5),757-761.
MLA Wang, YH,et al."New isoprenylated flavones, artochamins A-E, and cytotoxic principles from Artocarpus chama".JOURNAL OF NATURAL PRODUCTS 67.5(2004):757-761.
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