| Cytotoxic 3,20-Epoxy-ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora |
| Niu, XM; Li, SH ; Mei, SX; Na, Z; Zhao, QS; Lin, ZW; Sun, HD
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| 2002-12-01
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| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864
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| 卷号 | 65期号:12页码:1892-1896 |
| 摘要 | Four new ent-kaurane diterpenoids, laxiflorins J-M (1-4), along with maoecrystal A (5) and maoecrystal P (6), were isolated from the leaves of Isodon eriocalyx var. laxiflora. Their structures were determined by spectroscopic analyses. All the compounds were assayed for their cytotoxic effects on human tumor K562, A549, and T24 cell lines. Compounds 1 and 6 showed significant inhibitory effects on human tumor K562 and T24 cells, with IC50 values less than 0.5 mug/mL. Compound 3 also demonstrated cytotoxic activities against all three types of human tumor cells, with IC50 values in the range of 1-25 mug/mL. |
| 关键词 | Heracleum Rapula
Coumarin Glucosides
Furanocoumarin
Bicoumarin
Angelica-archangelica
Coumarins
Glucosides
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| 学科领域 | Plant Sciences
; Chemistry, Medicinal
; Pharmacology & Pharmacy
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| DOI | 10.1021/np020059e
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| 收录类别 | SCI
; IC
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| 语种 | 英语
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| WOS记录号 | WOS:000180190100028
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kib.ac.cn/handle/151853/4590
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| 专题 | 植物化学与西部植物资源持续利用国家重点实验室
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| 作者单位 | Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
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推荐引用方式
GB/T 7714 |
Niu, XM,Li, SH,Mei, SX,et al. Cytotoxic 3,20-Epoxy-ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora[J]. JOURNAL OF NATURAL PRODUCTS,2002,65(12):1892-1896.
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| APA |
Niu, XM.,Li, SH.,Mei, SX.,Na, Z.,Zhao, QS.,...&Sun, HD.(2002).Cytotoxic 3,20-Epoxy-ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora.JOURNAL OF NATURAL PRODUCTS,65(12),1892-1896.
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| MLA |
Niu, XM,et al."Cytotoxic 3,20-Epoxy-ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora".JOURNAL OF NATURAL PRODUCTS 65.12(2002):1892-1896.
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