Cytotoxic 3,20-Epoxy-ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora
Niu, XM; Li, SH; Mei, SX; Na, Z; Zhao, QS; Lin, ZW; Sun, HD
2002-12-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号65期号:12页码:1892-1896
摘要Four new ent-kaurane diterpenoids, laxiflorins J-M (1-4), along with maoecrystal A (5) and maoecrystal P (6), were isolated from the leaves of Isodon eriocalyx var. laxiflora. Their structures were determined by spectroscopic analyses. All the compounds were assayed for their cytotoxic effects on human tumor K562, A549, and T24 cell lines. Compounds 1 and 6 showed significant inhibitory effects on human tumor K562 and T24 cells, with IC50 values less than 0.5 mug/mL. Compound 3 also demonstrated cytotoxic activities against all three types of human tumor cells, with IC50 values in the range of 1-25 mug/mL.
关键词Heracleum Rapula Coumarin Glucosides Furanocoumarin Bicoumarin Angelica-archangelica Coumarins Glucosides
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np020059e
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000180190100028
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4590
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
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Niu, XM,Li, SH,Mei, SX,et al. Cytotoxic 3,20-Epoxy-ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora[J]. JOURNAL OF NATURAL PRODUCTS,2002,65(12):1892-1896.
APA Niu, XM.,Li, SH.,Mei, SX.,Na, Z.,Zhao, QS.,...&Sun, HD.(2002).Cytotoxic 3,20-Epoxy-ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora.JOURNAL OF NATURAL PRODUCTS,65(12),1892-1896.
MLA Niu, XM,et al."Cytotoxic 3,20-Epoxy-ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora".JOURNAL OF NATURAL PRODUCTS 65.12(2002):1892-1896.
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