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题名: Cytotoxic 3,20-Epoxy-ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora
作者: Niu, XM; null(黎胜红); Mei, SX; Na, Z; null(赵勤实); Lin, ZW; null(孙汉董)
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: Heracleum rapula ; coumarin glucosides ; furanocoumarin ; bicoumarin ; ANGELICA-ARCHANGELICA ; COUMARINS ; GLUCOSIDES
英文摘要: Four new ent-kaurane diterpenoids, laxiflorins J-M (1-4), along with maoecrystal A (5) and maoecrystal P (6), were isolated from the leaves of Isodon eriocalyx var. laxiflora. Their structures were determined by spectroscopic analyses. All the compounds were assayed for their cytotoxic effects on human tumor K562, A549, and T24 cell lines. Compounds 1 and 6 showed significant inhibitory effects on human tumor K562 and T24 cells, with IC50 values less than 0.5 mug/mL. Compound 3 also demonstrated cytotoxic activities against all three types of human tumor cells, with IC50 values in the range of 1-25 mug/mL.
出版日期: 2002-12-01
卷号: 65, 期号:12, 页码:1892-1896
DOI标识: 10.1021/np020059e
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4590
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Niu, XM; Li, SH; Mei, SX; Na, Z; Zhao, QS; Lin, ZW; Sun, HD.Cytotoxic 3,20-Epoxy-ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora,JOURNAL OF NATURAL PRODUCTS,2002,65(12):1892-1896
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