Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata
Zhang, HJ; Fan, ZT; Tan, GT; Chai, HB; Pezzuto, JM; Sun, HD; Fong, HHS
Corresponding AuthorSun, HD, Acad Sinica, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2002-02-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume65Issue:2Pages:215-217
AbstractA new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell, lines with IC50 values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) mug/mL (muM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np010420h
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000174048900024
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4582
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Acad Sinica, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA
3.Xizang Plateau Inst Biol, Lasa 850001, Peoples R China
Recommended Citation
GB/T 7714
Zhang, HJ,Fan, ZT,Tan, GT,et al. Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata[J]. JOURNAL OF NATURAL PRODUCTS,2002,65(2):215-217.
APA Zhang, HJ.,Fan, ZT.,Tan, GT.,Chai, HB.,Pezzuto, JM.,...&Fong, HHS.(2002).Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata.JOURNAL OF NATURAL PRODUCTS,65(2),215-217.
MLA Zhang, HJ,et al."Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata".JOURNAL OF NATURAL PRODUCTS 65.2(2002):215-217.
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