Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia

doi:10.1021/np0200257

	Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia
	Zhao, Y ; Hao, XJ; Lu, W ; Cai, JC ; Yu, H ; Sevenet, T ; Gueritte, F
通讯作者	Zhao, Y, Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Peoples R China
	2002-06-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	65 期号:6 页码:902-908
摘要	Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2-methylbutenyl) derivatives (34 and 35) were also synthesized. The cytotoxicities of 6 and 7 were measured using A-549, HL-60, and KB cancer cell lines.
关键词	Rabdosia
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np0200257
收录类别	IC ; CCR ; SCI
语种	英语
WOS记录号	WOS:000176688300018
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4580
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 4.Inmore Lab Biotechnol, Kunming 650011, Peoples R China 5.CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
推荐引用方式 GB/T 7714	Zhao, Y,Hao, XJ,Lu, W,et al. Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia[J]. JOURNAL OF NATURAL PRODUCTS,2002,65(6):902-908.
APA	Zhao, Y.,Hao, XJ.,Lu, W.,Cai, JC.,Yu, H.,...&Gueritte, F.(2002).Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia.JOURNAL OF NATURAL PRODUCTS,65(6),902-908.
MLA	Zhao, Y,et al."Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia".JOURNAL OF NATURAL PRODUCTS 65.6(2002):902-908.

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