Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia
Zhao, Y; Hao, XJ; Lu, W; Cai, JC; Yu, H; Sevenet, T; Gueritte, F
2002-06-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号65期号:6页码:902-908
摘要Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2-methylbutenyl) derivatives (34 and 35) were also synthesized. The cytotoxicities of 6 and 7 were measured using A-549, HL-60, and KB cancer cell lines.
关键词Rabdosia
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np0200257
收录类别IC ; CCR ; SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000176688300018
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4580
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
4.Inmore Lab Biotechnol, Kunming 650011, Peoples R China
5.CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
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Zhao, Y,Hao, XJ,Lu, W,et al. Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia[J]. JOURNAL OF NATURAL PRODUCTS,2002,65(6):902-908.
APA Zhao, Y.,Hao, XJ.,Lu, W.,Cai, JC.,Yu, H.,...&Gueritte, F.(2002).Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia.JOURNAL OF NATURAL PRODUCTS,65(6),902-908.
MLA Zhao, Y,et al."Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia".JOURNAL OF NATURAL PRODUCTS 65.6(2002):902-908.
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