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题名: Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia
作者: Zhao, Y; null(郝小江); Lu, W; Cai, JC; Yu, H; Sevenet, T; Gueritte, F
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: RABDOSIA
英文摘要: Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2-methylbutenyl) derivatives (34 and 35) were also synthesized. The cytotoxicities of 6 and 7 were measured using A-549, HL-60, and KB cancer cell lines.
出版日期: 2002-06-01
卷号: 65, 期号:6, 页码:902-908
DOI标识: 10.1021/np0200257
语种: 英语
收录类别: IC ; CCR ; SCI
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4580
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
4.Inmore Lab Biotechnol, Kunming 650011, Peoples R China
5.CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

Recommended Citation:
Zhao, Y; Hao, XJ; Lu, W; Cai, JC; Yu, H; Sevenet, T; Gueritte, F.Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia,JOURNAL OF NATURAL PRODUCTS,2002,65(6):902-908
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