Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis
Hou, AJ; Fukai, T; Shimazaki, M; Sakagami, H; Sun, HD; Nomura, T
Corresponding AuthorNomura, T, Toho Univ, Fac Pharmaceut Sci, 2-2-1 Miyama, Funabashi, Chiba 2748510, Japan
2001
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume64Issue:1Pages:65-70
AbstractFour new benzophenones with two isoprenoid groups, cudraphenones A-D (1-4), and three new xanthones also with two isoprenoid units, cudraxanthones P-R (5-7), were isolated from the roots of Cudrania cochinchinensis, together with 19 known phenolic compounds. The structures of the new compounds were elucidated by spectroscopic methods. Some compounds exhibited weak cytotoxicity against human oral squamous carcinoma cells (HSC-8) and normal human gingival fibroblasts (HGF). Among them, benzophenones 1-4 showed more potent cytotoxic activities against HSC-2 cells than against HGF cells. On the other hand, xanthones bearing isoprenoid groups showed much lower tumor specificity as compared with the benzophenones, except for geronthxanthone H and isoalvaxanthone. The presence of two sets of hydrophobic and hydrophilic groups in separate domains in each molecule might play a role in the mediation of tumor-specific action.
KeywordCerebroside
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
Indexed ByIC ; SCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000166696400014
Citation statistics
Cited Times:54[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4548
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan
2.Meikai Univ Sch Dent, Dept Dent Pharmacol, Sakado, Saitama 3500283, Japan
3.Acad Sinica, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Hou, AJ,Fukai, T,Shimazaki, M,et al. Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis[J]. JOURNAL OF NATURAL PRODUCTS,2001,64(1):65-70.
APA Hou, AJ,Fukai, T,Shimazaki, M,Sakagami, H,Sun, HD,&Nomura, T.(2001).Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis.JOURNAL OF NATURAL PRODUCTS,64(1),65-70.
MLA Hou, AJ,et al."Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis".JOURNAL OF NATURAL PRODUCTS 64.1(2001):65-70.
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