Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis
Hou, AJ; Fukai, T; Shimazaki, M; Sakagami, H; Sun, HD; Nomura, T
2001
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号64期号:1页码:65-70
摘要Four new benzophenones with two isoprenoid groups, cudraphenones A-D (1-4), and three new xanthones also with two isoprenoid units, cudraxanthones P-R (5-7), were isolated from the roots of Cudrania cochinchinensis, together with 19 known phenolic compounds. The structures of the new compounds were elucidated by spectroscopic methods. Some compounds exhibited weak cytotoxicity against human oral squamous carcinoma cells (HSC-8) and normal human gingival fibroblasts (HGF). Among them, benzophenones 1-4 showed more potent cytotoxic activities against HSC-2 cells than against HGF cells. On the other hand, xanthones bearing isoprenoid groups showed much lower tumor specificity as compared with the benzophenones, except for geronthxanthone H and isoalvaxanthone. The presence of two sets of hydrophobic and hydrophilic groups in separate domains in each molecule might play a role in the mediation of tumor-specific action.
关键词Cerebroside
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别IC ; SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000166696400014
引用统计
被引频次:52[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4548
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan
2.Meikai Univ Sch Dent, Dept Dent Pharmacol, Sakado, Saitama 3500283, Japan
3.Acad Sinica, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China
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GB/T 7714
Hou, AJ,Fukai, T,Shimazaki, M,et al. Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis[J]. JOURNAL OF NATURAL PRODUCTS,2001,64(1):65-70.
APA Hou, AJ,Fukai, T,Shimazaki, M,Sakagami, H,Sun, HD,&Nomura, T.(2001).Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis.JOURNAL OF NATURAL PRODUCTS,64(1),65-70.
MLA Hou, AJ,et al."Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis".JOURNAL OF NATURAL PRODUCTS 64.1(2001):65-70.
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