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题名: Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis
作者: Hou, AJ; Fukai, T; Shimazaki, M; Sakagami, H; null(孙汉董); Nomura, T
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: CEREBROSIDE
英文摘要: Four new benzophenones with two isoprenoid groups, cudraphenones A-D (1-4), and three new xanthones also with two isoprenoid units, cudraxanthones P-R (5-7), were isolated from the roots of Cudrania cochinchinensis, together with 19 known phenolic compounds. The structures of the new compounds were elucidated by spectroscopic methods. Some compounds exhibited weak cytotoxicity against human oral squamous carcinoma cells (HSC-8) and normal human gingival fibroblasts (HGF). Among them, benzophenones 1-4 showed more potent cytotoxic activities against HSC-2 cells than against HGF cells. On the other hand, xanthones bearing isoprenoid groups showed much lower tumor specificity as compared with the benzophenones, except for geronthxanthone H and isoalvaxanthone. The presence of two sets of hydrophobic and hydrophilic groups in separate domains in each molecule might play a role in the mediation of tumor-specific action.
出版日期: 2001
卷号: 64, 期号:1, 页码:65-70
语种: 英语
ISSN号: 0163-3864
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4548
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan
2.Meikai Univ Sch Dent, Dept Dent Pharmacol, Sakado, Saitama 3500283, Japan
3.Acad Sinica, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Hou, AJ; Fukai, T; Shimazaki, M; Sakagami, H; Sun, HD; Nomura, T.Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis,JOURNAL OF NATURAL PRODUCTS,2001,64(1):65-70
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