Crystal and molecular structures of a natural equimolecular mixture of two epimeric diterpenes
Sun, HD; Qiu, SX; Lobkovsky, EB; Lin, LZ; Farnsworth, NR; Clardy, J; Fong, HHS
2001
发表期刊TETRAHEDRON
ISSN0040-4020
卷号57期号:1页码:65-70
摘要Irroratin A (1), isolated from the aerial Darts of Isodon irrorata (Forrest.) (Labiatae), was shown to be an equimolecular mixture of two C-20 epimers of a new ent-kaurene diterpene both in the crystalline state and pyridine solution, based on X-ray, LC/MS/MS, FABMS as well as extensive 1D- and 2D-NMR spectral analysis. The two epimers were hound together by hydrogen bonds, and when in chloroform and methanol solution, the 20S-epimer predominates. Irroratin A exhibited potent cytotoxicity against several human cancer cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved.
关键词Acetals Terpenoids Isodon Irrorata Complexes Epimerisation
收录类别IC ; SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4524
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
3.Cornell Univ, Dept Chem, Baker Lab, Ithaca, NY 14850 USA
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Sun, HD,Qiu, SX,Lobkovsky, EB,et al. Crystal and molecular structures of a natural equimolecular mixture of two epimeric diterpenes[J]. TETRAHEDRON,2001,57(1):65-70.
APA Sun, HD.,Qiu, SX.,Lobkovsky, EB.,Lin, LZ.,Farnsworth, NR.,...&Fong, HHS.(2001).Crystal and molecular structures of a natural equimolecular mixture of two epimeric diterpenes.TETRAHEDRON,57(1),65-70.
MLA Sun, HD,et al."Crystal and molecular structures of a natural equimolecular mixture of two epimeric diterpenes".TETRAHEDRON 57.1(2001):65-70.
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