Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus-castus
Li, SH; Zhang, HJ; Qiu, SX; Niu, XM; Santarsiero, BD; Mesecar, AD; Fong, HHS; Farnsworth, NR; Sun, HD
AbstractA novel labdane diterpene alkaloid, vitexlactam A (1) was isolated as a prism from the n-hexane extract of the fruits of Vitex agnus-castus through normal and reverse phase column chromatography. Its structure was elucidated to be 6beta-acetoxy-9alpha-hydroxy-13(14)-labden-16,15-amide, based on chemical and spectral evidences including 1D and 2D NMR spectra. The structure was confirmed by X-ray crystallographic analysis. Compound 1 is the first naturally occurring labdane diterpenoid containing an alpha,beta-unsaturated gamma-lactam moiety. (C) 2002 Elsevier Science Ltd. All rights reserved.
KeywordVitex Agnus-castus Verbenaceae Labdane Diterpene Lactam Vitexlactam a Nmr X-ray
Subject AreaChemistry, Organic
Indexed ByIC ; SCI
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000176639100030
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA
3.Herbstandard Inc, Chesterfield, MO 63017 USA
4.Univ Illinois, Dept Med Chem & Pharmacognosy, Chicago, IL 60607 USA
5.Univ Illinois, Ctr Pharmaceut Biotechnol, Chicago, IL 60607 USA
6.Univ Illinois, UIC NIH Ctr Bot Dietary Supplements Res, Chicago, IL 60612 USA
Recommended Citation
GB/T 7714
Li, SH,Zhang, HJ,Qiu, SX,et al. Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus-castus[J]. TETRAHEDRON LETTERS,2002,43(29):5131-5134.
APA Li, SH.,Zhang, HJ.,Qiu, SX.,Niu, XM.,Santarsiero, BD.,...&Sun, HD.(2002).Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus-castus.TETRAHEDRON LETTERS,43(29),5131-5134.
MLA Li, SH,et al."Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus-castus".TETRAHEDRON LETTERS 43.29(2002):5131-5134.
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