Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis
Wang, Peng-Cheng1,3; Ran, Xin-Hui1; Chen, Rui1; Li, Liang-Chun4; Xiong, Shan-Shan5; Liu, Yu-Qing1; Luo, Huai-Rong1; Zhou, Jun1; Zhao, You-Xing1,2
2010-10-13
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号51期号:41页码:5451-5453
摘要Volvalerenone A (1), a new type of mononorsesquiterpenoid with an unprecedented 5/6/6 tricyclic ring system, was isolated from the roots of Valeriana officinalis, the official species of valerian used in Europe. The structure of volvalerenone A was elucidated based on its spectroscopic and single-crystal X-ray crystallography data. The absolute configuration was assigned by the computational method. A possible bio-synthetic pathway of volvalerenone A was also proposed. Preliminary biological studies showed that volvalerenone A had weak inhibitory activity on acetylcholine esterase (AChE), and no enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells was observed at 50 mu M. (C) 2010 Elsevier Ltd. All rights reserved.
关键词Valeriana Officinalis Valerianacae Mononorsesquiterpenoid Volvalerenone a Ache Inhibitory Activity
资助信息State Key Laboratory of Phytochemistry and Plant Resources in West China [P2008-ZZ22]; Natural Science foundation of Yunnan [2008CD 159]
学科领域Chemistry, Organic
DOI10.1016/j.tetlet.2010.08.023
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000282381000026
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4314
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China
5.Yunnan Univ, Dept Chem, Kunming 650091, Peoples R China
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Wang, Peng-Cheng,Ran, Xin-Hui,Chen, Rui,et al. Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis[J]. TETRAHEDRON LETTERS,2010,51(41):5451-5453.
APA Wang, Peng-Cheng.,Ran, Xin-Hui.,Chen, Rui.,Li, Liang-Chun.,Xiong, Shan-Shan.,...&Zhao, You-Xing.(2010).Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis.TETRAHEDRON LETTERS,51(41),5451-5453.
MLA Wang, Peng-Cheng,et al."Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis".TETRAHEDRON LETTERS 51.41(2010):5451-5453.
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