Swerilactones E-G, three unusual lactones from Swertia mileensis
Geng, Chang-An1,2; Zhang, Xue-Mei1; Ma, Yun-Bao1; Jiang, Zhi-Yong1; Luo, Jie1; Zhou, Jun1; Wang, Hong-Ling1,2; Chen, Ji-Jun1
2010-05-05
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号51期号:18页码:2483-2485
摘要Swerilactones E (1), F (2), and G (3), three unusual lactones with a phenyl group, were isolated from the traditional Chinese herb of Sweat mileensis. Their structures were determined based on extensive spectroscopic analysis and X-ray single crystal crystallography. Our anti-HBV assay on the Hep G 2.2.15 cell line in vitro showed that compounds 1 and 2 exhibited significant inhibitory activities against the secretion of HBsAg with IC(50) of 0.22 and 0.70 mM and HBeAg with IC(50) of 0.52 and >6.78 nM, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
关键词Swertia Mileensis Swerilactones E-g Secoiridoid Aglycone Anti Hbv Activity
资助信息National Natural Science Foundation of China [U0832603]; National Natural Science Foundation of Yunnan Province [U0832603]; Major Project of Innovative Engineering [KSCX2-YW-R-181]; Chinese Academy of Sciences ; State Key Laboratory of Phytochemistry and Plant Resources in West China
学科领域Chemistry, Organic
DOI10.1016/j.tetlet.2010.02.156
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000276972200027
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4304
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Geng, Chang-An,Zhang, Xue-Mei,Ma, Yun-Bao,et al. Swerilactones E-G, three unusual lactones from Swertia mileensis[J]. TETRAHEDRON LETTERS,2010,51(18):2483-2485.
APA Geng, Chang-An.,Zhang, Xue-Mei.,Ma, Yun-Bao.,Jiang, Zhi-Yong.,Luo, Jie.,...&Chen, Ji-Jun.(2010).Swerilactones E-G, three unusual lactones from Swertia mileensis.TETRAHEDRON LETTERS,51(18),2483-2485.
MLA Geng, Chang-An,et al."Swerilactones E-G, three unusual lactones from Swertia mileensis".TETRAHEDRON LETTERS 51.18(2010):2483-2485.
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