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题名: Swerilactones E-G, three unusual lactones from Swertia mileensis
作者: Geng, Chang-An1, 2; Zhang, Xue-Mei1; Ma, Yun-Bao1; Jiang, Zhi-Yong1; Luo, Jie1; Zhou, Jun1; Wang, Hong-Ling1, 2; null(陈纪军)1
刊名: TETRAHEDRON LETTERS
关键词: Swertia mileensis ; Swerilactones E-G ; Secoiridoid aglycone ; Anti HBV activity
英文摘要: Swerilactones E (1), F (2), and G (3), three unusual lactones with a phenyl group, were isolated from the traditional Chinese herb of Sweat mileensis. Their structures were determined based on extensive spectroscopic analysis and X-ray single crystal crystallography. Our anti-HBV assay on the Hep G 2.2.15 cell line in vitro showed that compounds 1 and 2 exhibited significant inhibitory activities against the secretion of HBsAg with IC(50) of 0.22 and 0.70 mM and HBeAg with IC(50) of 0.52 and >6.78 nM, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
出版日期: 2010-05-05
卷号: 51, 期号:18, 页码:2483-2485
DOI标识: 10.1016/j.tetlet.2010.02.156
语种: 英语
ISSN号: 0040-4039
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4304
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Geng, CA; Zhang, XM; Ma, YB; Jiang, ZY; Luo, J; Zhou, J; Wang, HL; Chen, JJ.Swerilactones E-G, three unusual lactones from Swertia mileensis,TETRAHEDRON LETTERS,2010,51(18):2483-2485
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