Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis
Fan, Jun-Ting1,2; Chen, Yi-Shan1,2; Xu, Wen-Yan1,2,3; Du, Liangcheng3; Zeng, Guang-Zhi1; Zhang, Yu-Mei1; Su, Jia1; Li, Yan1; Tan, Ning-Hua1
2010-12-29
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号51期号:52页码:6810-6813
摘要Two novel cyclic hexapeptides, named rubiyunnanins A (1) and B (2), were isolated from the roots of Rubia yunnanensis (Franch.) Diels. Their structures were elucidated extensively by spectroscopic analysis and theoretical computation. Possible biosynthetic pathways for RAs, 1, and 2 were proposed. Compound 2 showed moderate cytotoxicities against 11 cancer cell lines and inhibited nitric oxide (NO) production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages. (C) 2010 Elsevier Ltd. All rights reserved.
关键词Rubia Yunnanensis Rubiyunnanin a Rubiyunnanin b Cyclopeptides Cytotoxicity Inhibition Of No Production
资助信息National Natural Science Foundation of China [30725048]; National Basic Research Program of China [2009 CB522300]; Science and Technology Department of Yunnan Province [2008OC011]; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
学科领域Chemistry, Organic
DOI10.1016/j.tetlet.2010.07.066
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000285670400004
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4300
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA
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Fan, Jun-Ting,Chen, Yi-Shan,Xu, Wen-Yan,et al. Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis[J]. TETRAHEDRON LETTERS,2010,51(52):6810-6813.
APA Fan, Jun-Ting.,Chen, Yi-Shan.,Xu, Wen-Yan.,Du, Liangcheng.,Zeng, Guang-Zhi.,...&Tan, Ning-Hua.(2010).Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis.TETRAHEDRON LETTERS,51(52),6810-6813.
MLA Fan, Jun-Ting,et al."Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis".TETRAHEDRON LETTERS 51.52(2010):6810-6813.
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