Acortatarins A and B, Two Novel Antioxidative Spiroalkaloids with a Naturally Unusual Morpholine Motif from Acorus tatarinowii
Tong, Xiao-Gang2,3; Zhou, Li-Li1; Wang, Yue-Hu2; Xia, Chengfeng2; Wang, Ye4,5; Liang, Min; Hou, Fan-Fan1; Cheng, Yong-Xian2
2010-04-16
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号12期号:8页码:1844-1847
摘要Acortatarins A (1) and B (2), two novel spiroalkaloids with a naturally unusual morpholine motif, were isolated from the rhizome of Acorus tatarinowii. Their structures with absolute configuration were determined by spectroscopic methods, X-ray diffraction analysis, and Masher's method. Importantly, compound 1 could significantly inhibit reactive oxygen species production in high-glucose-stimulated mesangial cells in a dose- and time-dependent manner.
关键词High-glucose Mesangial Cells Expression Inhibitors Activation Products Oxidase Acid
资助信息Chinese Academy of Sciences (CAS) [KSCX2-YW-R-118, KSCX2-YW-R-211]; Yunnan Youth [2007PY01-48]; Kunming Institute of Botany [P2008-ZZ11]; National Natural Science Foundation [30830056]
学科领域Chemistry, Organic
DOI10.1021/ol100451p
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000276562600050
引用统计
被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4282
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.So Med Univ, Div Nephrol, Nanfang Hosp, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Guangdong, Peoples R China
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Chinese Acad Sci, Guiyang 550002, Guizhou, Peoples R China
5.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Guizhou, Peoples R China
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Tong, Xiao-Gang,Zhou, Li-Li,Wang, Yue-Hu,et al. Acortatarins A and B, Two Novel Antioxidative Spiroalkaloids with a Naturally Unusual Morpholine Motif from Acorus tatarinowii[J]. ORGANIC LETTERS,2010,12(8):1844-1847.
APA Tong, Xiao-Gang.,Zhou, Li-Li.,Wang, Yue-Hu.,Xia, Chengfeng.,Wang, Ye.,...&Cheng, Yong-Xian.(2010).Acortatarins A and B, Two Novel Antioxidative Spiroalkaloids with a Naturally Unusual Morpholine Motif from Acorus tatarinowii.ORGANIC LETTERS,12(8),1844-1847.
MLA Tong, Xiao-Gang,et al."Acortatarins A and B, Two Novel Antioxidative Spiroalkaloids with a Naturally Unusual Morpholine Motif from Acorus tatarinowii".ORGANIC LETTERS 12.8(2010):1844-1847.
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