Swerilactones C and D, anti-HBV New Lactones from a Traditional Chinese Herb: Swertia mileensis
Geng, Chang-An1,2; Zhang, Xue-Mei1; Shen, Yong1,2; Zuo, Ai-Xue1,2; Liu, Ji-Feng1,2; Ma, Yun-Bao1; Luo, Jia1; Zhou, Jun1; Jiang, Zhi-yong1; Chen, Ji-Jun1
2009-11-05
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号11期号:21页码:4838-4841
摘要Swerilactones C (1) and D (2), two novel diastereomeric lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb Swertia mileensis. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic methods and further confirmed by X-ray single-crystal diffraction analysis. In vitro antihepatitis 8 virus (HBV) assay on the Hep G 2.2.15 cell line showed that both compounds 1 and 2 exhibited Inhibitory activities against the secretion of HBsAg (IC(50) = 1.24 and 2.96 mM, respectively) and HBeAg (IC(50) = 0.77 and 1.47 mM, respectively).
关键词Hepatitis-b-virus Iridoids
资助信息National Natural Science Foundation of China and Yunnan Province [U0832603]; Xibu Zhiguang Joint-Scholarship
学科领域Chemistry, Organic
DOI10.1021/ol901881w
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000271097100019
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4266
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Geng, Chang-An,Zhang, Xue-Mei,Shen, Yong,et al. Swerilactones C and D, anti-HBV New Lactones from a Traditional Chinese Herb: Swertia mileensis[J]. ORGANIC LETTERS,2009,11(21):4838-4841.
APA Geng, Chang-An.,Zhang, Xue-Mei.,Shen, Yong.,Zuo, Ai-Xue.,Liu, Ji-Feng.,...&Chen, Ji-Jun.(2009).Swerilactones C and D, anti-HBV New Lactones from a Traditional Chinese Herb: Swertia mileensis.ORGANIC LETTERS,11(21),4838-4841.
MLA Geng, Chang-An,et al."Swerilactones C and D, anti-HBV New Lactones from a Traditional Chinese Herb: Swertia mileensis".ORGANIC LETTERS 11.21(2009):4838-4841.
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