Swerilactones C and D, anti-HBV New Lactones from a Traditional Chinese Herb: Swertia mileensis

doi:10.1021/ol901881w

	Swerilactones C and D, anti-HBV New Lactones from a Traditional Chinese Herb: Swertia mileensis
	Geng, Chang-An1,2 ; Zhang, Xue-Mei1 ; Shen, Yong 1,2; Zuo, Ai-Xue 1,2; Liu, Ji-Feng 1,2; Ma, Yun-Bao 1; Luo, Jia 1; Zhou, Jun1 ; Jiang, Zhi-yong 1; Chen, Ji-Jun1
	2009-11-05
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	11 期号:21 页码:4838-4841
摘要	Swerilactones C (1) and D (2), two novel diastereomeric lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb Swertia mileensis. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic methods and further confirmed by X-ray single-crystal diffraction analysis. In vitro antihepatitis 8 virus (HBV) assay on the Hep G 2.2.15 cell line showed that both compounds 1 and 2 exhibited Inhibitory activities against the secretion of HBsAg (IC(50) = 1.24 and 2.96 mM, respectively) and HBeAg (IC(50) = 0.77 and 1.47 mM, respectively).
关键词	Hepatitis-b-virus Iridoids
学科领域	Chemistry, Organic
DOI	10.1021/ol901881w
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000271097100019
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4266
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Geng, Chang-An,Zhang, Xue-Mei,Shen, Yong,et al. Swerilactones C and D, anti-HBV New Lactones from a Traditional Chinese Herb: Swertia mileensis[J]. ORGANIC LETTERS,2009,11(21):4838-4841.
APA	Geng, Chang-An.,Zhang, Xue-Mei.,Shen, Yong.,Zuo, Ai-Xue.,Liu, Ji-Feng.,...&Chen, Ji-Jun.(2009).Swerilactones C and D, anti-HBV New Lactones from a Traditional Chinese Herb: Swertia mileensis.ORGANIC LETTERS,11(21),4838-4841.
MLA	Geng, Chang-An,et al."Swerilactones C and D, anti-HBV New Lactones from a Traditional Chinese Herb: Swertia mileensis".ORGANIC LETTERS 11.21(2009):4838-4841.

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