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题名: Swerilactones C and D, anti-HBV New Lactones from a Traditional Chinese Herb: Swertia mileensis
作者: Geng, Chang-An1, 2; Zhang, Xue-Mei1; Shen, Yong1, 2; Zuo, Ai-Xue1, 2; Liu, Ji-Feng1, 2; Ma, Yun-Bao1; Luo, Jia1; Zhou, Jun1; Jiang, Zhi-yong1; null(陈纪军)1
刊名: ORGANIC LETTERS
关键词: HEPATITIS-B-VIRUS ; IRIDOIDS
英文摘要: Swerilactones C (1) and D (2), two novel diastereomeric lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb Swertia mileensis. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic methods and further confirmed by X-ray single-crystal diffraction analysis. In vitro antihepatitis 8 virus (HBV) assay on the Hep G 2.2.15 cell line showed that both compounds 1 and 2 exhibited Inhibitory activities against the secretion of HBsAg (IC(50) = 1.24 and 2.96 mM, respectively) and HBeAg (IC(50) = 0.77 and 1.47 mM, respectively).
出版日期: 2009-11-05
卷号: 11, 期号:21, 页码:4838-4841
DOI标识: 10.1021/ol901881w
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry, Organic
ISSN号: 1523-7060
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4266
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Geng, CA; Zhang, XM; Shen, Y; Zuo, AX; Liu, JF; Ma, YB; Luo, J; Zhou, J; Jiang, ZY; Chen, JJ.Swerilactones C and D, anti-HBV New Lactones from a Traditional Chinese Herb: Swertia mileensis,ORGANIC LETTERS,2009,11(21):4838-4841
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