Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis

doi:10.1021/ol901592f

	Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis
	Geng, Chang-An1,2 ; Jiang, Zhi-Yong 1; Ma, Yun-Bao 1; Luo, Jie 1; Zhang, Xue-Mei1 ; Wang, Hong-Ling 1,2; Shen, Yong 1,2; Zuo, Ai-Xue 1,2; Zhou, Jun1 ; Chen, Ji-Jun1
	2009-09-17
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	11 期号:18 页码:4120-4123
摘要	Swerilactones A (1) and B (2), two novel lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb of Swertia mileensis with activity against the hepatitis virus. Their structures and relative stereochemistry were elucidated based on spectroscopic methods and further confirmed by X-ray single crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on Hep G 2.2.15 cell line showed that compound 1 inhibited HBsAg and HBeAg secretion with IC(50) values of 3.66 and 3.58 mM, respectively.
关键词	Lamivudine Therapy Virus Alkaloids Constituents
学科领域	Chemistry, Organic
DOI	10.1021/ol901592f
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000269670700024
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4264
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Geng, Chang-An,Jiang, Zhi-Yong,Ma, Yun-Bao,et al. Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis[J]. ORGANIC LETTERS,2009,11(18):4120-4123.
APA	Geng, Chang-An.,Jiang, Zhi-Yong.,Ma, Yun-Bao.,Luo, Jie.,Zhang, Xue-Mei.,...&Chen, Ji-Jun.(2009).Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis.ORGANIC LETTERS,11(18),4120-4123.
MLA	Geng, Chang-An,et al."Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis".ORGANIC LETTERS 11.18(2009):4120-4123.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
201201060047.pdf（203KB）			开放获取	--	浏览下载